Decreased influenza virus pathogenesis by infection with germicidal UV-irradiated airborne virus

George J. Jakab, Mardel E. Knight

Research output: Contribution to journalArticle

Abstract

Respiratory infections are acquired by the inhalation of airborne microorganisms. To evaluate the effect of germicidal UV-irradiation on airborne contagion, infectious clouds of influenza A/PR8/34 virus were generated and exposed to known intensities of UV. Thereafter, the airborne virus was used to infect mice wherein the pathogenesis of the viral pneumonia was evaluated. Increasing doses of UV inactivated infectious airborne virus in a dose-dependent manner and reduced the mortality rates as compared to an infectious cloud of untreated virus. When a sublethal cloud of infectious virus was used, UV-irradiation modified the viral infection, as quantitated by pulmonary virus titers, from a severe pneumonitis to a milder form of the disease. These data demonstrate the efficacy of germicidal UV-irradiation in disinfection of air by reducing the concentration of viable organisms which, in turn, reduces the severity of respiratory infection when transmitted to the susceptible host.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalEnvironment International
Volume8
Issue number1-6
DOIs
StatePublished - 1982

Fingerprint

influenza
Viruses
virus
irradiation
Irradiation
pneumonia
Disinfection
Microorganisms
disinfection
infection
microorganism
mortality
air
Air

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Decreased influenza virus pathogenesis by infection with germicidal UV-irradiated airborne virus. / Jakab, George J.; Knight, Mardel E.

In: Environment International, Vol. 8, No. 1-6, 1982, p. 415-418.

Research output: Contribution to journalArticle

Jakab, George J. ; Knight, Mardel E. / Decreased influenza virus pathogenesis by infection with germicidal UV-irradiated airborne virus. In: Environment International. 1982 ; Vol. 8, No. 1-6. pp. 415-418.
@article{3b8cbacb94104ea8b0128163433b326e,
title = "Decreased influenza virus pathogenesis by infection with germicidal UV-irradiated airborne virus",
abstract = "Respiratory infections are acquired by the inhalation of airborne microorganisms. To evaluate the effect of germicidal UV-irradiation on airborne contagion, infectious clouds of influenza A/PR8/34 virus were generated and exposed to known intensities of UV. Thereafter, the airborne virus was used to infect mice wherein the pathogenesis of the viral pneumonia was evaluated. Increasing doses of UV inactivated infectious airborne virus in a dose-dependent manner and reduced the mortality rates as compared to an infectious cloud of untreated virus. When a sublethal cloud of infectious virus was used, UV-irradiation modified the viral infection, as quantitated by pulmonary virus titers, from a severe pneumonitis to a milder form of the disease. These data demonstrate the efficacy of germicidal UV-irradiation in disinfection of air by reducing the concentration of viable organisms which, in turn, reduces the severity of respiratory infection when transmitted to the susceptible host.",
author = "Jakab, {George J.} and Knight, {Mardel E.}",
year = "1982",
doi = "10.1016/0160-4120(82)90059-9",
language = "English (US)",
volume = "8",
pages = "415--418",
journal = "Environmental International",
issn = "0160-4120",
publisher = "Elsevier Limited",
number = "1-6",

}

TY - JOUR

T1 - Decreased influenza virus pathogenesis by infection with germicidal UV-irradiated airborne virus

AU - Jakab, George J.

AU - Knight, Mardel E.

PY - 1982

Y1 - 1982

N2 - Respiratory infections are acquired by the inhalation of airborne microorganisms. To evaluate the effect of germicidal UV-irradiation on airborne contagion, infectious clouds of influenza A/PR8/34 virus were generated and exposed to known intensities of UV. Thereafter, the airborne virus was used to infect mice wherein the pathogenesis of the viral pneumonia was evaluated. Increasing doses of UV inactivated infectious airborne virus in a dose-dependent manner and reduced the mortality rates as compared to an infectious cloud of untreated virus. When a sublethal cloud of infectious virus was used, UV-irradiation modified the viral infection, as quantitated by pulmonary virus titers, from a severe pneumonitis to a milder form of the disease. These data demonstrate the efficacy of germicidal UV-irradiation in disinfection of air by reducing the concentration of viable organisms which, in turn, reduces the severity of respiratory infection when transmitted to the susceptible host.

AB - Respiratory infections are acquired by the inhalation of airborne microorganisms. To evaluate the effect of germicidal UV-irradiation on airborne contagion, infectious clouds of influenza A/PR8/34 virus were generated and exposed to known intensities of UV. Thereafter, the airborne virus was used to infect mice wherein the pathogenesis of the viral pneumonia was evaluated. Increasing doses of UV inactivated infectious airborne virus in a dose-dependent manner and reduced the mortality rates as compared to an infectious cloud of untreated virus. When a sublethal cloud of infectious virus was used, UV-irradiation modified the viral infection, as quantitated by pulmonary virus titers, from a severe pneumonitis to a milder form of the disease. These data demonstrate the efficacy of germicidal UV-irradiation in disinfection of air by reducing the concentration of viable organisms which, in turn, reduces the severity of respiratory infection when transmitted to the susceptible host.

UR - http://www.scopus.com/inward/record.url?scp=0020285253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020285253&partnerID=8YFLogxK

U2 - 10.1016/0160-4120(82)90059-9

DO - 10.1016/0160-4120(82)90059-9

M3 - Article

VL - 8

SP - 415

EP - 418

JO - Environmental International

JF - Environmental International

SN - 0160-4120

IS - 1-6

ER -