Decreased hippocampal muscarinic cholinergic receptor binding measured by 123I‐iododexetimide and single‐photon emission computed tomography in epilepsy

Hans W. Müller‐Gärtner, Helen S. Mayberg, Robert S. Fisher, Ronald P. Lesser, Alan A. Wilson, Hayden T. Ravert, Robert F. Dannals, Henry N. Wagner, Sumio Uematsu, J. James Frost

Research output: Contribution to journalArticlepeer-review

Abstract

Regional binding of 123I‐iododexetimide, a muscarinic acetylchline receptor antagonist, was measured in vivo in the temporal lobes of 4 patients with complex partial seizures using single‐photon emissions computed tomography. In the anterior hippocampus ipsilateral to the electrical focus, 123I‐iododexetimide binding was decreased by 40 ± 9% (mean 7plusmn; SD, p <0.01) compared with the contralateral hippocampus; 123I‐iododexetimide binding in other temporal lobe regions was symmetrical. The data indicate a regionally specific change of muscarinic acetylcholine receptor in anterior hippocampus in complex partial seizures of temporal lobe origin.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalAnnals of neurology
Volume34
Issue number2
DOIs
StatePublished - Aug 1993

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Decreased hippocampal muscarinic cholinergic receptor binding measured by <sup>123</sup>I‐iododexetimide and single‐photon emission computed tomography in epilepsy'. Together they form a unique fingerprint.

Cite this