Decreased hemispheric connectivity and decreased intra- and inter- hemisphere asymmetry of resting state functional network connectivity in schizophrenia

O. Agcaoglu, R. Miller, E. Damaraju, B. Rashid, J. Bustillo, M. S. Cetin, T. G.M. van Erp, S. McEwen, A. Preda, J. M. Ford, K. O. Lim, D. S. Manoach, D. H. Mathalon, S. G. Potkin, Vince Daniel Calhoun

Research output: Contribution to journalArticle

Abstract

Many studies have shown that schizophrenia patients have aberrant functional network connectivity (FNC) among brain regions, suggesting schizophrenia manifests with significantly diminished (in majority of the cases) connectivity. Schizophrenia is also associated with a lack of hemispheric lateralization. Hoptman et al. (2012) reported lower inter-hemispheric connectivity in schizophrenia patients compared to controls using voxel-mirrored homotopic connectivity. In this study, we merge these two points of views together using a group independent component analysis (gICA)-based approach to generate hemisphere-specific timecourses and calculate intra-hemisphere and inter-hemisphere FNC on a resting state fMRI dataset consisting of age- and gender-balanced 151 schizophrenia patients and 163 healthy controls. We analyzed the group differences between patients and healthy controls in each type of FNC measures along with age and gender effects. The results reveal that FNC in schizophrenia patients shows less hemispheric asymmetry compared to that of the healthy controls. We also found a decrease in connectivity in all FNC types such as intra-left (L_FNC), intra-right (R_FNC) and inter-hemisphere (Inter_FNC) in the schizophrenia patients relative to healthy controls, but general patterns of connectivity were preserved in patients. Analyses of age and gender effects yielded results similar to those reported in whole brain FNC studies.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalBrain Imaging and Behavior
DOIs
StateAccepted/In press - Apr 22 2017
Externally publishedYes

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Schizophrenia
Brain
Magnetic Resonance Imaging

Keywords

  • Functional network connectivity
  • Hemisphere
  • Heterotopic connectivity
  • Homotopic connectivity
  • Lateral connectivity
  • Laterality
  • Schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience

Cite this

Decreased hemispheric connectivity and decreased intra- and inter- hemisphere asymmetry of resting state functional network connectivity in schizophrenia. / Agcaoglu, O.; Miller, R.; Damaraju, E.; Rashid, B.; Bustillo, J.; Cetin, M. S.; van Erp, T. G.M.; McEwen, S.; Preda, A.; Ford, J. M.; Lim, K. O.; Manoach, D. S.; Mathalon, D. H.; Potkin, S. G.; Calhoun, Vince Daniel.

In: Brain Imaging and Behavior, 22.04.2017, p. 1-16.

Research output: Contribution to journalArticle

Agcaoglu, O, Miller, R, Damaraju, E, Rashid, B, Bustillo, J, Cetin, MS, van Erp, TGM, McEwen, S, Preda, A, Ford, JM, Lim, KO, Manoach, DS, Mathalon, DH, Potkin, SG & Calhoun, VD 2017, 'Decreased hemispheric connectivity and decreased intra- and inter- hemisphere asymmetry of resting state functional network connectivity in schizophrenia', Brain Imaging and Behavior, pp. 1-16. https://doi.org/10.1007/s11682-017-9718-7
Agcaoglu, O. ; Miller, R. ; Damaraju, E. ; Rashid, B. ; Bustillo, J. ; Cetin, M. S. ; van Erp, T. G.M. ; McEwen, S. ; Preda, A. ; Ford, J. M. ; Lim, K. O. ; Manoach, D. S. ; Mathalon, D. H. ; Potkin, S. G. ; Calhoun, Vince Daniel. / Decreased hemispheric connectivity and decreased intra- and inter- hemisphere asymmetry of resting state functional network connectivity in schizophrenia. In: Brain Imaging and Behavior. 2017 ; pp. 1-16.
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AU - Rashid, B.

AU - Bustillo, J.

AU - Cetin, M. S.

AU - van Erp, T. G.M.

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AU - Preda, A.

AU - Ford, J. M.

AU - Lim, K. O.

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AU - Calhoun, Vince Daniel

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