Decreased Epstein-Barr virus-induced transformation, and elevated 2-5A synthetase and RNase L activity in peripheral blood mononuclear cells from patients treated with recombinant interferon alfa 2b

Gerald E. Fronko, Robert J. Suhadolnik, Eric C. Vonderheid, Katalin Karikó, Nancy L. Reichenbach, Kenneth D. Chavin, Earl E. Henderson

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with cutaneous T-cell lymphoma (CTCL) were treated with recombinant alfa 2b interferon (rIFN alfa 2b) by intramuscular injection. Therapy-induced changes in Epstein-Barr virus (EBV) induced transformation of patient peripheral blood lymphocytes, 2′,5′ oligoadenylate (2-5A) synthetase levels and RNase L activation in peripheral blood mononuclear cells were monitored. Inhibition of EBV-induced transformation and elevation of 2-5A synthetase levels correlated with increased activation of RNase L, which provides evidence that intramuscular administration of rIFN alfa 2b induces a sustained anti-EBV state in CTCL patient peripheral blood mononuclear cells which can be detected in vitro.

Original languageEnglish (US)
Pages (from-to)448-453
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume153
Issue number1
DOIs
StatePublished - May 31 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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