Decreased effect of immunosuppression on immunocompetence in African - Americans after kidney and liver transplantation

Naoki Nagashima, Takuji Watanabe, Michio Nakamura, Ahmed Shalabi, James F. Burdick

Research output: Contribution to journalArticle

Abstract

Several studies indicate that the poorer outcomes for African-Americans after transplantation may be due to decreased effectiveness of immunosuppressive agents. Using an in vitro test of immunocompetence (IMC), we measured the effects of immunosuppression on African-American, compared with Caucasian, kidney or liver transplantation recipients. The IMC result was the highest of three mixed lymphocyte culture responses using validated stimulator cell pools. A total of 293 tests were done in Caucasians and 144 in African-Americans. Overall, the IMC for African-Americans was 38, compared with 19 for Caucasians (p

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalClinical Transplantation
Volume15
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Immunocompetence
African Americans
Liver Transplantation
Kidney Transplantation
Immunosuppression
Immunosuppressive Agents
Transplantation
Lymphocytes

Keywords

  • African-American
  • Cyclosporine
  • Immunocompetence
  • Immunosuppression
  • Kidney transplantation
  • Liver transplantation
  • Lymphocyte activation
  • Mycophenolate mofetil
  • Tacrolimus

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Decreased effect of immunosuppression on immunocompetence in African - Americans after kidney and liver transplantation. / Nagashima, Naoki; Watanabe, Takuji; Nakamura, Michio; Shalabi, Ahmed; Burdick, James F.

In: Clinical Transplantation, Vol. 15, No. 2, 2001, p. 111-115.

Research output: Contribution to journalArticle

Nagashima, Naoki ; Watanabe, Takuji ; Nakamura, Michio ; Shalabi, Ahmed ; Burdick, James F. / Decreased effect of immunosuppression on immunocompetence in African - Americans after kidney and liver transplantation. In: Clinical Transplantation. 2001 ; Vol. 15, No. 2. pp. 111-115.
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