Decreased ebola transmission after rapid response to outbreaks in remote areas, Liberia, 2014

Kim A. Lindblade; Francis Kateh; Thomas K. Nagbe; John C. Neatherlin; Satish K. Pillai; Kathleen R. Attfield; Emmanuel Dweh; Danielle T. Barradas; Seymour G. Williams; David J. Blackley; Hannah L. Kirking; Monita R. Patel; Monica Dea; Mehran S. Massoudi; Kathleen Wannemuehler; Albert E. Barskey; Shauna L.Mettee Zarecki; Moses Fomba; Steven Grube; Lisa Belcher; Laura N. Broyles; T. Nikki Maxwell; Jose E. Hagan; Kristin Yeoman; Matthew Westercamp; Joseph Forrester; Joshua Mott; Frank Mahoney; Laurence Slutsker; Kevin M. Decock; Tolbert Nyenswah

doi:10.3201/eid2110.150912

Decreased ebola transmission after rapid response to outbreaks in remote areas, Liberia, 2014

Kim A. Lindblade, Francis Kateh, Thomas K. Nagbe, John C. Neatherlin, Satish K. Pillai, Kathleen R. Attfield, Emmanuel Dweh, Danielle T. Barradas, Seymour G. Williams, David J. Blackley, Hannah L. Kirking, Monita R. Patel, Monica Dea, Mehran S. Massoudi, Kathleen Wannemuehler, Albert E. Barskey, Shauna L.Mettee Zarecki, Moses Fomba, Steven Grube, Lisa BelcherLaura N. Broyles, T. Nikki Maxwell, Jose E. Hagan, Kristin Yeoman, Matthew Westercamp, Joseph Forrester, Joshua Mott, Frank Mahoney, Laurence Slutsker, Kevin M. Decock, Tolbert Nyenswah

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1–2.6) to 0.1 (95% CI 0.02–0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04–0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60–74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4–0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.

Original language	English (US)
Pages (from-to)	1800-1807
Number of pages	8
Journal	Emerging infectious diseases
Volume	21
Issue number	10
DOIs	https://doi.org/10.3201/eid2110.150912
State	Published - Sep 1 2015
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Lindblade, K. A., Kateh, F., Nagbe, T. K., Neatherlin, J. C., Pillai, S. K., Attfield, K. R., Dweh, E., Barradas, D. T., Williams, S. G., Blackley, D. J., Kirking, H. L., Patel, M. R., Dea, M., Massoudi, M. S., Wannemuehler, K., Barskey, A. E., Zarecki, S. L. M., Fomba, M., Grube, S., ... Nyenswah, T. (2015). Decreased ebola transmission after rapid response to outbreaks in remote areas, Liberia, 2014. Emerging infectious diseases, 21(10), 1800-1807. https://doi.org/10.3201/eid2110.150912

Lindblade, KA, Kateh, F, Nagbe, TK, Neatherlin, JC, Pillai, SK, Attfield, KR, Dweh, E, Barradas, DT, Williams, SG, Blackley, DJ, Kirking, HL, Patel, MR, Dea, M, Massoudi, MS, Wannemuehler, K, Barskey, AE, Zarecki, SLM, Fomba, M, Grube, S, Belcher, L, Broyles, LN, Maxwell, TN, Hagan, JE, Yeoman, K, Westercamp, M, Forrester, J, Mott, J, Mahoney, F, Slutsker, L, Decock, KM & Nyenswah, T 2015, 'Decreased ebola transmission after rapid response to outbreaks in remote areas, Liberia, 2014', Emerging infectious diseases, vol. 21, no. 10, pp. 1800-1807. https://doi.org/10.3201/eid2110.150912

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abstract = "We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1–2.6) to 0.1 (95% CI 0.02–0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04–0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60–74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4–0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.",

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AU - Mott, Joshua

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Decreased ebola transmission after rapid response to outbreaks in remote areas, Liberia, 2014

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