Decreased ebola transmission after rapid response to outbreaks in remote areas, Liberia, 2014

Kim A. Lindblade, Francis Kateh, Thomas K. Nagbe, John C. Neatherlin, Satish K. Pillai, Kathleen R. Attfield, Emmanuel Dweh, Danielle T. Barradas, Seymour G. Williams, David J. Blackley, Hannah L. Kirking, Monita R. Patel, Monica Dea, Mehran S. Massoudi, Kathleen Wannemuehler, Albert E. Barskey, Shauna L.Mettee Zarecki, Moses Fomba, Steven Grube, Lisa BelcherLaura N. Broyles, T. Nikki Maxwell, Jose E. Hagan, Kristin Yeoman, Matthew Westercamp, Joseph Forrester, Joshua Mott, Frank Mahoney, Laurence Slutsker, Kevin M. Decock, Tolbert Nyenswah

Research output: Contribution to journalArticlepeer-review


We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1–2.6) to 0.1 (95% CI 0.02–0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04–0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60–74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4–0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.

Original languageEnglish (US)
Pages (from-to)1800-1807
Number of pages8
JournalEmerging infectious diseases
Issue number10
StatePublished - Sep 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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