Decreased counts of blood neutrophils, monocytes, and platelets in human immunodeficiency virus-infected children and young adults treated with diethyldithiocarbamate

J. L. Shenep, W. T. Hughes, P. M. Flynn, P. K. Roberson, F. G. Behm, G. H. Fullen, S. G. Kovnar, K. P. Guito, T. O. Brodkey

Research output: Contribution to journalComment/debatepeer-review

Abstract

Nineteen young human immunodeficiency virus-infected patients were randomized to receive 400 mg of oral diethyldithiocarbamate (DTC) per m2 or placebo weekly for 12 weeks. Changes in blood CD4+ lymphocytes were not significantly different between groups. However, neutrophil, monocyte, and platelet counts consistently decreased during DTC treatment, suggesting DTC- mediated myelosuppression.

Original languageEnglish (US)
Pages (from-to)1644-1646
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume38
Issue number7
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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