TY - JOUR
T1 - Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant
AU - Brown, Marilyn R.
AU - Thunberg, Barbara J.
AU - Golub, Leonard
AU - Maniscalco, William M.
AU - Cox, Christopher
AU - Shapiro, Donald L.
PY - 1989/7
Y1 - 1989/7
N2 - Thirty to 50% of very low-birth-weight infants have parenteral nutrition-associated cholestasis. To test the hypothesis that the incidence of cholestasis would be decreased if parenteral amino acids were avoided and protein given enterally, infants with a gestational age of <30 weeks were randomized to two groups. One group received amino acid-free parenteral nutrition and whey protein enterally with added premature infant formula. The control group received standard parenteral nutrition with amino acids and enteral premature formula. At the end of 3 weeks of parenteral nutrition, infants who had a direct serum bilirubin level of >3 mg/dl were considered to have significant cholestasis. Twenty-nine infants required parenteral nutrition for 3 weeks, 17 in the whey group and 12 in the control group. No instances of significant cholestasis were observed in the whey group (0/17), whereas seven of 12 infants (58%) in the amino acid control group had cholestasis (p < 0.001).
AB - Thirty to 50% of very low-birth-weight infants have parenteral nutrition-associated cholestasis. To test the hypothesis that the incidence of cholestasis would be decreased if parenteral amino acids were avoided and protein given enterally, infants with a gestational age of <30 weeks were randomized to two groups. One group received amino acid-free parenteral nutrition and whey protein enterally with added premature infant formula. The control group received standard parenteral nutrition with amino acids and enteral premature formula. At the end of 3 weeks of parenteral nutrition, infants who had a direct serum bilirubin level of >3 mg/dl were considered to have significant cholestasis. Twenty-nine infants required parenteral nutrition for 3 weeks, 17 in the whey group and 12 in the control group. No instances of significant cholestasis were observed in the whey group (0/17), whereas seven of 12 infants (58%) in the amino acid control group had cholestasis (p < 0.001).
KW - Cholestasis
KW - Intravenous amino acids
KW - Parenteral nutrition
KW - Protein
KW - Very low-birth-weight infant
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U2 - 10.1097/00005176-198909010-00005
DO - 10.1097/00005176-198909010-00005
M3 - Article
C2 - 2506323
AN - SCOPUS:0024391627
SN - 0277-2116
VL - 9
SP - 21
EP - 27
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 1
ER -