Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant

Marilyn R. Brown, Barbara J. Thunberg, Leonard Golub, William M. Maniscalco, Christopher Cox, Donald L. Shapiro

Research output: Contribution to journalArticle

Abstract

Thirty to 50% of very low-birth-weight infants have parenteral nutrition-associated cholestasis. To test the hypothesis that the incidence of cholestasis would be decreased if parenteral amino acids were avoided and protein given enterally, infants with a gestational age of 3 mg/dl were considered to have significant cholestasis. Twenty-nine infants required parenteral nutrition for 3 weeks, 17 in the whey group and 12 in the control group. No instances of significant cholestasis were observed in the whey group (0/17), whereas seven of 12 infants (58%) in the amino acid control group had cholestasis (p <0.001).

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume9
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

cholestasis
Very Low Birth Weight Infant
low birth weight
Cholestasis
Small Intestine
infant nutrition
Parenteral Nutrition
parenteral feeding
Proteins
whey
proteins
Amino Acids
Control Groups
amino acids
gestational age
Gestational Age
incidence
Incidence
testing

Keywords

  • Cholestasis
  • Intravenous amino acids
  • Parenteral nutrition
  • Protein
  • Very low-birth-weight infant

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Medicine (miscellaneous)
  • Histology

Cite this

Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant. / Brown, Marilyn R.; Thunberg, Barbara J.; Golub, Leonard; Maniscalco, William M.; Cox, Christopher; Shapiro, Donald L.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 9, No. 1, 1989, p. 21-27.

Research output: Contribution to journalArticle

Brown, Marilyn R. ; Thunberg, Barbara J. ; Golub, Leonard ; Maniscalco, William M. ; Cox, Christopher ; Shapiro, Donald L. / Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant. In: Journal of Pediatric Gastroenterology and Nutrition. 1989 ; Vol. 9, No. 1. pp. 21-27.
@article{ede9462c241c4a168df6cc5f4172320a,
title = "Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant",
abstract = "Thirty to 50{\%} of very low-birth-weight infants have parenteral nutrition-associated cholestasis. To test the hypothesis that the incidence of cholestasis would be decreased if parenteral amino acids were avoided and protein given enterally, infants with a gestational age of 3 mg/dl were considered to have significant cholestasis. Twenty-nine infants required parenteral nutrition for 3 weeks, 17 in the whey group and 12 in the control group. No instances of significant cholestasis were observed in the whey group (0/17), whereas seven of 12 infants (58{\%}) in the amino acid control group had cholestasis (p <0.001).",
keywords = "Cholestasis, Intravenous amino acids, Parenteral nutrition, Protein, Very low-birth-weight infant",
author = "Brown, {Marilyn R.} and Thunberg, {Barbara J.} and Leonard Golub and Maniscalco, {William M.} and Christopher Cox and Shapiro, {Donald L.}",
year = "1989",
language = "English (US)",
volume = "9",
pages = "21--27",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant

AU - Brown, Marilyn R.

AU - Thunberg, Barbara J.

AU - Golub, Leonard

AU - Maniscalco, William M.

AU - Cox, Christopher

AU - Shapiro, Donald L.

PY - 1989

Y1 - 1989

N2 - Thirty to 50% of very low-birth-weight infants have parenteral nutrition-associated cholestasis. To test the hypothesis that the incidence of cholestasis would be decreased if parenteral amino acids were avoided and protein given enterally, infants with a gestational age of 3 mg/dl were considered to have significant cholestasis. Twenty-nine infants required parenteral nutrition for 3 weeks, 17 in the whey group and 12 in the control group. No instances of significant cholestasis were observed in the whey group (0/17), whereas seven of 12 infants (58%) in the amino acid control group had cholestasis (p <0.001).

AB - Thirty to 50% of very low-birth-weight infants have parenteral nutrition-associated cholestasis. To test the hypothesis that the incidence of cholestasis would be decreased if parenteral amino acids were avoided and protein given enterally, infants with a gestational age of 3 mg/dl were considered to have significant cholestasis. Twenty-nine infants required parenteral nutrition for 3 weeks, 17 in the whey group and 12 in the control group. No instances of significant cholestasis were observed in the whey group (0/17), whereas seven of 12 infants (58%) in the amino acid control group had cholestasis (p <0.001).

KW - Cholestasis

KW - Intravenous amino acids

KW - Parenteral nutrition

KW - Protein

KW - Very low-birth-weight infant

UR - http://www.scopus.com/inward/record.url?scp=0024391627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024391627&partnerID=8YFLogxK

M3 - Article

C2 - 2506323

AN - SCOPUS:0024391627

VL - 9

SP - 21

EP - 27

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 1

ER -