Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: A confirmation in drug-free patients and correlation with white matter hyperintensity

Tadafumi Kato, Jun Murashita, Atsushi Kamiya, Toshiki Shioiri, Nobumasa Kato, Toshiro Inubushi

Research output: Contribution to journalArticlepeer-review

Abstract

The authors have previously reported decreased intracellular pH (pHi) in the frontal lobes in euthymic bipolar patients treated with lithium using 31P-MRS. White matter hyperintensity (WMHI) is frequently seen in bipolar disorder. To examine a possible effect of lithium on pHi and the relationship between pHi and WMHI, seven drug-free euthymic bipolar patients were examined, and T2-weighted MRI were examined in 14 previously reported bipolar patients. Drug-free patients showed significantly lower pHi than controls. WMHI was associated with low pHi and increased phosphodiester peak. These results suggest that decrease of pHi is not an effect of lithium but is instead related to the pathophysiology of illness. Decrease of pHi and increase of the PDE peak may be the biochemical basis of WMHI in bipolar disorder.

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume248
Issue number6
DOIs
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Bipolar affective disorder
  • Magnetic resonance imaging
  • Mood disorder
  • Phosphorus-31 magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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