Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

William F. Byerley, Elizabeth J. McConnell, R. Tyler McCabe, Ted M. Dawson, Bernard I. Grosser, James K. Wamsley

Research output: Contribution to journalArticlepeer-review

Abstract

Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]-dihydroalprenolol ([3H]-DHA) decreased significantly in frontal cortex layers. Analysis of saturation experiments indicated that the reduction was due to a change in number but not affinity of [3H-DHA binding sites. The data support the hypothesis that the mechanism of action of most antidepressant compounds involves a change in beta-adrenergic receptor function.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalPsychopharmacology
Volume94
Issue number1
DOIs
StatePublished - Mar 1 1988
Externally publishedYes

Keywords

  • Antidepressant
  • Beta-adrenergic receptor
  • Fluoxetine
  • In vitro receptor autoradiography
  • Serotonin
  • [H-Dihydroalprenolol

ASJC Scopus subject areas

  • Pharmacology

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