Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

William F. Byerley, Elizabeth J. McConnell, R. Tyler McCabe, Ted M Dawson, Bernard I. Grosser, James K. Wamsley

Research output: Contribution to journalArticle

Abstract

Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]-dihydroalprenolol ([3H]-DHA) decreased significantly in frontal cortex layers. Analysis of saturation experiments indicated that the reduction was due to a change in number but not affinity of [3H-DHA binding sites. The data support the hypothesis that the mechanism of action of most antidepressant compounds involves a change in beta-adrenergic receptor function.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalPsychopharmacology
Volume94
Issue number1
DOIs
StatePublished - Mar 1988
Externally publishedYes

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Keywords

  • [H-Dihydroalprenolol
  • Antidepressant
  • Beta-adrenergic receptor
  • Fluoxetine
  • In vitro receptor autoradiography
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

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