Abstract
Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]-dihydroalprenolol ([3H]-DHA) decreased significantly in frontal cortex layers. Analysis of saturation experiments indicated that the reduction was due to a change in number but not affinity of [3H-DHA binding sites. The data support the hypothesis that the mechanism of action of most antidepressant compounds involves a change in beta-adrenergic receptor function.
Original language | English (US) |
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Pages (from-to) | 141-143 |
Number of pages | 3 |
Journal | Psychopharmacology |
Volume | 94 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 1988 |
Externally published | Yes |
Keywords
- Antidepressant
- Beta-adrenergic receptor
- Fluoxetine
- In vitro receptor autoradiography
- Serotonin
- [H-Dihydroalprenolol
ASJC Scopus subject areas
- Pharmacology