Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

William F. Byerley; Elizabeth J. McConnell; R. Tyler McCabe; Ted M Dawson; Bernard I. Grosser; James K. Wamsley

doi:10.1007/BF00735896

Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

William F. Byerley, Elizabeth J. McConnell, R. Tyler McCabe, Ted M Dawson, Bernard I. Grosser, James K. Wamsley

Research output: Contribution to journal › Article

Abstract

Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [³H]-dihydroalprenolol ([³H]-DHA) decreased significantly in frontal cortex layers. Analysis of saturation experiments indicated that the reduction was due to a change in number but not affinity of [³H-DHA binding sites. The data support the hypothesis that the mechanism of action of most antidepressant compounds involves a change in beta-adrenergic receptor function.

Original language	English (US)
Pages (from-to)	141-143
Number of pages	3
Journal	Psychopharmacology
Volume	94
Issue number	1
DOIs	https://doi.org/10.1007/BF00735896
State	Published - Mar 1988
Externally published	Yes

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Keywords

[H-Dihydroalprenolol
Antidepressant
Beta-adrenergic receptor
Fluoxetine
In vitro receptor autoradiography
Serotonin

ASJC Scopus subject areas

Pharmacology

Cite this

Byerley, W. F., McConnell, E. J., McCabe, R. T., Dawson, T. M., Grosser, B. I., & Wamsley, J. K. (1988). Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine. Psychopharmacology, 94(1), 141-143. https://doi.org/10.1007/BF00735896

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10.1007/BF00735896