Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

William F. Byerley; Elizabeth J. McConnell; R. Tyler McCabe; Ted M. Dawson; Bernard I. Grosser; James K. Wamsley

doi:10.1007/BF00735896

Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

William F. Byerley, Elizabeth J. McConnell, R. Tyler McCabe, Ted M. Dawson, Bernard I. Grosser, James K. Wamsley

Research output: Contribution to journal › Article › peer-review

Abstract

Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [³H]-dihydroalprenolol ([³H]-DHA) decreased significantly in frontal cortex layers. Analysis of saturation experiments indicated that the reduction was due to a change in number but not affinity of [³H-DHA binding sites. The data support the hypothesis that the mechanism of action of most antidepressant compounds involves a change in beta-adrenergic receptor function.

Original language	English (US)
Pages (from-to)	141-143
Number of pages	3
Journal	Psychopharmacology
Volume	94
Issue number	1
DOIs	https://doi.org/10.1007/BF00735896
State	Published - Mar 1 1988
Externally published	Yes

Keywords

Antidepressant
Beta-adrenergic receptor
Fluoxetine
In vitro receptor autoradiography
Serotonin
[H-Dihydroalprenolol

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1007/BF00735896

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Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine. / Byerley, William F.; McConnell, Elizabeth J.; McCabe, R. Tyler; Dawson, Ted M.; Grosser, Bernard I.; Wamsley, James K.

In: Psychopharmacology, Vol. 94, No. 1, 01.03.1988, p. 141-143.

Research output: Contribution to journal › Article › peer-review

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