Abstract
Endothelial cell function and angiogenesis are modulated by aging. However, the underlying molecular mechanisms are largely unknown. Here we show that in telomerase-deficient mice Terc-/-, short telomeres result in a sharp decrease in angiogenesis in both Matrigel implants and murine melanoma grafts. In the latter model, decreased microvessel counts in late generation Terc-/- mice led to diminished tumor cell proliferation and increased tumor cell apoptosis, resulting in a lower tumor growth rate. Our results indicate that telomere length is a key molecular determinant of angiogenic potential in vivo and that telomere length modifiers and telomerase inhibitors could be useful antiangiogenic agents.
Original language | English (US) |
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Pages (from-to) | 552-559 |
Number of pages | 8 |
Journal | Cancer Research |
Volume | 62 |
Issue number | 2 |
State | Published - Jan 15 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research