Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres

Sonia Franco, Inmaculada Segura, Hans H. Riese, María A. Blasco

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelial cell function and angiogenesis are modulated by aging. However, the underlying molecular mechanisms are largely unknown. Here we show that in telomerase-deficient mice Terc-/-, short telomeres result in a sharp decrease in angiogenesis in both Matrigel implants and murine melanoma grafts. In the latter model, decreased microvessel counts in late generation Terc-/- mice led to diminished tumor cell proliferation and increased tumor cell apoptosis, resulting in a lower tumor growth rate. Our results indicate that telomere length is a key molecular determinant of angiogenic potential in vivo and that telomere length modifiers and telomerase inhibitors could be useful antiangiogenic agents.

Original languageEnglish (US)
Pages (from-to)552-559
Number of pages8
JournalCancer Research
Volume62
Issue number2
StatePublished - Jan 15 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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