Decreased arterial dye-filling and venous dilation in the macular choroid associated with age-related macular degeneration

Keisuke Mori, Peter Gehlbach, Yoko Nishiyama Ito, Shin Yoneya

Research output: Contribution to journalArticle

Abstract

Purpose: To compare the angioarchitecture of choroidal arteries and veins in patients with age-related macular degeneration (AMD) to the angioarchitecture of age-matched normal subjects using indocyanine green (ICG) angiography. Methods: ICG angiography was performed in 35 consecutive AMD patients and 18 normal age-matched volunteers with a fundus ICG camera. ICG video images, including the arterial and venous phases, were quantitatively analyzed using image analyzing software. Results: In patients with AMD, the choroidal arterioles are dilated, fewer, run a straighter course, and possess fewer bifurcations. The number of choroidal arteries and the macular fluorescent intensity in the arterial phase of choroidal filling was significantly less in patients with AMD as compared to age-matched normal controls (P = 0.008). The mean and maximum caliber of choroidal veins in the macula was dilated in AMD eyes than in age-matched normal control eyes (P <0.001). There was no statistically significant difference in arterial dye filling or venous caliber observed in AMD eyes, with or without choroidal neovascular membrane (CNV). Conclusion: Choroidal arterial perfusion in the macula was significant decreased in eyes with AMD with and without CNV, and was associated with choroidal venous dilation. These observations implicate poor choroidal perfusion of the macula in the pathogenesis of AMD.

Original languageEnglish (US)
Pages (from-to)430-437
Number of pages8
JournalRetina
Volume25
Issue number4
DOIs
StatePublished - Jun 2005

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Choroid
Macular Degeneration
Dilatation
Coloring Agents
Indocyanine Green
Veins
Angiography
Arteries
Perfusion
Membranes
Arterioles
Volunteers
Software

Keywords

  • Age-related macular degeneration
  • Arterial dye-filling
  • Choroidal perfusion
  • Indocyanine green angiography
  • Venous dilation

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Decreased arterial dye-filling and venous dilation in the macular choroid associated with age-related macular degeneration. / Mori, Keisuke; Gehlbach, Peter; Ito, Yoko Nishiyama; Yoneya, Shin.

In: Retina, Vol. 25, No. 4, 06.2005, p. 430-437.

Research output: Contribution to journalArticle

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AB - Purpose: To compare the angioarchitecture of choroidal arteries and veins in patients with age-related macular degeneration (AMD) to the angioarchitecture of age-matched normal subjects using indocyanine green (ICG) angiography. Methods: ICG angiography was performed in 35 consecutive AMD patients and 18 normal age-matched volunteers with a fundus ICG camera. ICG video images, including the arterial and venous phases, were quantitatively analyzed using image analyzing software. Results: In patients with AMD, the choroidal arterioles are dilated, fewer, run a straighter course, and possess fewer bifurcations. The number of choroidal arteries and the macular fluorescent intensity in the arterial phase of choroidal filling was significantly less in patients with AMD as compared to age-matched normal controls (P = 0.008). The mean and maximum caliber of choroidal veins in the macula was dilated in AMD eyes than in age-matched normal control eyes (P <0.001). There was no statistically significant difference in arterial dye filling or venous caliber observed in AMD eyes, with or without choroidal neovascular membrane (CNV). Conclusion: Choroidal arterial perfusion in the macula was significant decreased in eyes with AMD with and without CNV, and was associated with choroidal venous dilation. These observations implicate poor choroidal perfusion of the macula in the pathogenesis of AMD.

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