Decrease in circulating endothelial progenitor cells in treated glioma patients

Elena Corsini, Emilio Ciusani, Paola Gaviani, Antonio Silvani, Alessandra Canazza, Gaetano Bernardi, Chiara Calatozzolo, Francesco Di Meco, Andrea Salmaggi

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


High-grade gliomas are highly vascularized tumors, in which the amount of new blood vessels is closely related with the degree of malignancy. The role of endothelial progenitor cells (EPCs) in the neoangiogenesis of gliomas and the effects of post-surgical therapies (i.e., radiotherapy (RT) and chemotherapy) have not yet been fully elucidated. The aim of the present study was to evaluate the effect of surgery and post-surgical treatment on the levels of circulating EPCs in glioma patients and their correlation with vascular endothelial growth factor (VEGF). In this study, we assessed by flow cytometry the number of EPCs in the peripheral blood of 78 high-grade glioma patients (both untreated and treated with RT and chemotherapy) and 34 age- and sex-matched healthy controls. EPCs were markedly decreased in all treated glioma patients as compared to untreated ones. VEGF levels were significantly higher in patients as compared to controls, and surgery, but not chemotherapy, significantly decreased VEGF concentrations. We found no relationship between VEGF plasma levels and EPCs. In conclusion, the reliability of EPCs as a biomarker for monitoring angiogenesis in glioma patients needs further studies of correlations of this parameter with other markers of tumor-related vasculature.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalJournal of Neuro-Oncology
Issue number1
StatePublished - May 2012


  • Angiogenesis
  • Chemotherapy
  • Circulating endothelial progenitor cells
  • Glioma
  • Radiotherapy
  • Surgery
  • VEGF

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology


Dive into the research topics of 'Decrease in circulating endothelial progenitor cells in treated glioma patients'. Together they form a unique fingerprint.

Cite this