Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts

P. O. Alderson, K. H. Douglass, K. G. Mendenhall, V. A. Guadiani, D. C. Watson, J. M. Links, H. N. Wagner

Research output: Contribution to journalArticlepeer-review


A poor bonus injection results in an unsatisfactory quantitative radionuclide angiocardiogram in as many as 20% of children with possible left-to-right (L-R) cardiac shunts. Deconvolution analysis was applied to similar studies in experimental animals to determine whether dependence on the input bolus could be minimized. Repeated good-bolus, prolonged (> 2.5 sec), or multiple-peak injections were made in four normal dogs and seven dogs with surgically created atrial defects (ASD). QP/QS was determined using the gamma function. The mean QP/QS from ten good-bolus studies in each animal was used as the standard for comparison. In five trials in normal animals, where a prolonged or double-peak bolus led to a shunt calculation (QP/QS ≥ 1.2:1), deconvolution resulted in QP/QS = 1.0. Deconvolution improved shunt quantitation in eight of ten trials in animals that received a prolonged bolus. The correlation between the reference QP/QS and the QP/QS calculated from uncorrected bad bolus studies was only 0.39 (p<0.01). After deconvolution using a low pass filter, the correlation improved significantly (r = 0.77, p 0.01). The technique gave inconsistent results with multiple-peak bolus injections. Deconvolution analysis in these studies is useful in preventing normals from being classified as shunts, and is improving shunt quantitation after a prolonged bolus. Clinical testing of this technique in children with suspected L-R shunts seems warranted.

Original languageEnglish (US)
Pages (from-to)502-506
Number of pages5
JournalJournal of Nuclear Medicine
Issue number6
StatePublished - Oct 15 1979
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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