Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts

P. O. Alderson, K. H. Douglass, K. G. Mendenhall, V. A. Guadiani, D. C. Watson, Jonathan M Links, H. N. Wagner

Research output: Contribution to journalArticle

Abstract

A poor bonus injection results in an unsatisfactory quantitative radionuclide angiocardiogram in as many as 20% of children with possible left-to-right (L-R) cardiac shunts. Deconvolution analysis was applied to similar studies in experimental animals to determine whether dependence on the input bolus could be minimized. Repeated good-bolus, prolonged (> 2.5 sec), or multiple-peak injections were made in four normal dogs and seven dogs with surgically created atrial defects (ASD). QP/QS was determined using the gamma function. The mean QP/QS from ten good-bolus studies in each animal was used as the standard for comparison. In five trials in normal animals, where a prolonged or double-peak bolus led to a shunt calculation (QP/QS ≥ 1.2:1), deconvolution resulted in QP/QS = 1.0. Deconvolution improved shunt quantitation in eight of ten trials in animals that received a prolonged bolus. The correlation between the reference QP/QS and the QP/QS calculated from uncorrected bad bolus studies was only 0.39 (p

Original languageEnglish (US)
Pages (from-to)502-506
Number of pages5
JournalJournal of Nuclear Medicine
Volume20
Issue number6
StatePublished - 1979
Externally publishedYes

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Radioisotopes
Dogs
Injections

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Alderson, P. O., Douglass, K. H., Mendenhall, K. G., Guadiani, V. A., Watson, D. C., Links, J. M., & Wagner, H. N. (1979). Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts. Journal of Nuclear Medicine, 20(6), 502-506.

Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts. / Alderson, P. O.; Douglass, K. H.; Mendenhall, K. G.; Guadiani, V. A.; Watson, D. C.; Links, Jonathan M; Wagner, H. N.

In: Journal of Nuclear Medicine, Vol. 20, No. 6, 1979, p. 502-506.

Research output: Contribution to journalArticle

Alderson, PO, Douglass, KH, Mendenhall, KG, Guadiani, VA, Watson, DC, Links, JM & Wagner, HN 1979, 'Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts', Journal of Nuclear Medicine, vol. 20, no. 6, pp. 502-506.
Alderson PO, Douglass KH, Mendenhall KG, Guadiani VA, Watson DC, Links JM et al. Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts. Journal of Nuclear Medicine. 1979;20(6):502-506.
Alderson, P. O. ; Douglass, K. H. ; Mendenhall, K. G. ; Guadiani, V. A. ; Watson, D. C. ; Links, Jonathan M ; Wagner, H. N. / Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts. In: Journal of Nuclear Medicine. 1979 ; Vol. 20, No. 6. pp. 502-506.
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