Decline in weight and incident mild cognitive impairment Mayo Clinic study of aging

Rabe E. Alhurani, Maria Vassilaki, Jeremiah A. Aakre, Michelle M. Mielke, Walter K. Kremers, Mary M. Machulda, Yonas E. Geda, David S. Knopman, Ronald C. Peterson, Rosebud O. Roberts

Research output: Contribution to journalArticlepeer-review


IMPORTANCE: Unintentional weight loss has been associated with risk of dementia. Because mild cognitive impairment (MCI) is a prodromal stage for dementia, we sought to evaluate whether changesin weight and body mass index (BMI) may predict incident MCI. OBJECTIVE: To investigate the association of change in weight and BMI with risk of MCI. DESIGN, SETTING, AND PARTICIPANTS: A population-based, prospective study of participants 70 years of age or older from the Mayo Clinic Study of Aging, which was initiated on October 1, 2004. Maximum weight and height in midlife (40-65 years of age) were retrospectively ascertained from the medical records of participants using a medical records-linkage system. The statistical analyses were performed between January and November 2015. MAINOUTCOMESAND MEASURES: Participants were evaluated for cognitive outcomes of normal cognition, MCI, or dementia at baseline and prospectively assessed for incident events at each 15-month evaluation. The association of rate of change in weight and BMI with risk of MCI was investigated using proportional hazards models. RESULTS: Over a mean follow-up of 4.4 years, 524 of 1895 cognitively normal participants developed incident MCI (50.3% were men; mean age, 78.5 years). The mean (SD) rate of weight change per decade from midlife to study entry was greater for participants who developed incident MCI vs those who remained cognitively normal (-2.0 [5.1] vs-1.2 [4.9] kg; P =.006). A greater decline in weight per decade was associated with an increased risk of incident MCI (hazard ratio [HR], 1.04 [95% CI, 1.02-1.06]; P

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalJAMA Neurology
Issue number4
StatePublished - Apr 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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