Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: A 1H NMR-based metabolomics study

Caigui Lin, Zhong Chen, Lingqiang Zhang, Zhiliang Wei, Kian Kai Cheng, Yueyue Liu, Guiping Shen, Haining Fan, Jiyang Dong

Research output: Contribution to journalArticle

Abstract

Background: Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (1H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE. Results: A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower (P < 0.001) in the blood serum obtained from the HAE patients than it was in the healthy patient group. Conclusions: The altered Fischer ratio, together with perturbations in metabolic pathways identified in the present study, may provide new insights into the mechanistic understanding of HAE pathogenesis and potential therapeutic interventions.

Original languageEnglish (US)
Article number300
JournalParasites and Vectors
Volume12
Issue number1
DOIs
StatePublished - Jun 13 2019

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Hepatic Echinococcosis
Metabolomics
Echinococcus multilocularis
Branched Chain Amino Acids
Aromatic Amino Acids
Parasitic Diseases
Metabolome
Metabolic Networks and Pathways
Serum
Energy Metabolism
Larva
Proton Magnetic Resonance Spectroscopy
Protons
Early Diagnosis
Magnetic Resonance Spectroscopy
Multivariate Analysis
Urine
Amino Acids
Liver
Growth

Keywords

  • Echinococcosis
  • Metabolomics
  • NMR

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis : A 1H NMR-based metabolomics study. / Lin, Caigui; Chen, Zhong; Zhang, Lingqiang; Wei, Zhiliang; Cheng, Kian Kai; Liu, Yueyue; Shen, Guiping; Fan, Haining; Dong, Jiyang.

In: Parasites and Vectors, Vol. 12, No. 1, 300, 13.06.2019.

Research output: Contribution to journalArticle

Lin, Caigui ; Chen, Zhong ; Zhang, Lingqiang ; Wei, Zhiliang ; Cheng, Kian Kai ; Liu, Yueyue ; Shen, Guiping ; Fan, Haining ; Dong, Jiyang. / Deciphering the metabolic perturbation in hepatic alveolar echinococcosis : A 1H NMR-based metabolomics study. In: Parasites and Vectors. 2019 ; Vol. 12, No. 1.
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