Abstract
Background. Accurate and reliable assessment of kidney quality before transplantation is needed to predict recipient outcomes and to optimize management and allocation of the allograft. The aim of this study was to systematically review the published literature on biomarkers in two mediums (the perfusate from deceased-donor kidneys receiving machine perfusion and deceased-donor urine) that were evaluated for their possible association with outcomes after kidney transplantation. Methods. We searched the Ovid Medline and Scopus databases using broad keywords related to deceased-donor biomarkers in kidney transplantation (limited to humans and the English language). Studies were included if they involved deceased-donor kidneys, measured perfusate or urine biomarkers and studied a possible relationship between biomarker concentrations and kidney allograft outcomes. Each included article was assessed for methodological quality. Results. Of 1430 abstracts screened, 29 studies met the inclusion criteria. Of these, 23 were studies of perfusate (16 biomarkers examined) and 6 were studies of urine (18 biomarkers examined). Only 3 studies (two perfusate) met the criteria of 'good' quality and only 12 were published since 2000. Perfusate lactate dehydrogenase, glutathione-S-transferase (GST) and aspartate transaminase were all found to be significantly associated with delayed graft function in a majority of their respective studies (6/9, 4/6 and 2/2 studies, respectively). Urine neutrophil gelatinase-associated lipocalin, GST, Trolox-equivalent antioxidant capacity and kidney injury molecule-1 were found to be significantly associated with allograft outcomes in single studies that examined diverse end points. Conclusion. Higher quality studies are needed to investigate modern kidney injury biomarkers, to validate novel biomarkers in larger donor populations and to determine the incremental predictive value of biomarkers over traditional clinical variables. Published by Oxford University Press on behalf of ERA-EDTA 2012. 2012
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3305-3314 |
| Number of pages | 10 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 27 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2012 |
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Keywords
- biomarkers
- deceased donors
- delayed graft function
- kidney transplantation
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
Deceased-donor kidney perfusate and urine biomarkers for kidney allograft outcomes : A systematic review. / Bhangoo, Ronik S.; Hall, Isaac E.; Reese, Peter P.; Parikh, Chirag.
In: Nephrology Dialysis Transplantation, Vol. 27, No. 8, 01.08.2012, p. 3305-3314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deceased-donor kidney perfusate and urine biomarkers for kidney allograft outcomes
T2 - A systematic review
AU - Bhangoo, Ronik S.
AU - Hall, Isaac E.
AU - Reese, Peter P.
AU - Parikh, Chirag
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Background. Accurate and reliable assessment of kidney quality before transplantation is needed to predict recipient outcomes and to optimize management and allocation of the allograft. The aim of this study was to systematically review the published literature on biomarkers in two mediums (the perfusate from deceased-donor kidneys receiving machine perfusion and deceased-donor urine) that were evaluated for their possible association with outcomes after kidney transplantation. Methods. We searched the Ovid Medline and Scopus databases using broad keywords related to deceased-donor biomarkers in kidney transplantation (limited to humans and the English language). Studies were included if they involved deceased-donor kidneys, measured perfusate or urine biomarkers and studied a possible relationship between biomarker concentrations and kidney allograft outcomes. Each included article was assessed for methodological quality. Results. Of 1430 abstracts screened, 29 studies met the inclusion criteria. Of these, 23 were studies of perfusate (16 biomarkers examined) and 6 were studies of urine (18 biomarkers examined). Only 3 studies (two perfusate) met the criteria of 'good' quality and only 12 were published since 2000. Perfusate lactate dehydrogenase, glutathione-S-transferase (GST) and aspartate transaminase were all found to be significantly associated with delayed graft function in a majority of their respective studies (6/9, 4/6 and 2/2 studies, respectively). Urine neutrophil gelatinase-associated lipocalin, GST, Trolox-equivalent antioxidant capacity and kidney injury molecule-1 were found to be significantly associated with allograft outcomes in single studies that examined diverse end points. Conclusion. Higher quality studies are needed to investigate modern kidney injury biomarkers, to validate novel biomarkers in larger donor populations and to determine the incremental predictive value of biomarkers over traditional clinical variables. Published by Oxford University Press on behalf of ERA-EDTA 2012. 2012
AB - Background. Accurate and reliable assessment of kidney quality before transplantation is needed to predict recipient outcomes and to optimize management and allocation of the allograft. The aim of this study was to systematically review the published literature on biomarkers in two mediums (the perfusate from deceased-donor kidneys receiving machine perfusion and deceased-donor urine) that were evaluated for their possible association with outcomes after kidney transplantation. Methods. We searched the Ovid Medline and Scopus databases using broad keywords related to deceased-donor biomarkers in kidney transplantation (limited to humans and the English language). Studies were included if they involved deceased-donor kidneys, measured perfusate or urine biomarkers and studied a possible relationship between biomarker concentrations and kidney allograft outcomes. Each included article was assessed for methodological quality. Results. Of 1430 abstracts screened, 29 studies met the inclusion criteria. Of these, 23 were studies of perfusate (16 biomarkers examined) and 6 were studies of urine (18 biomarkers examined). Only 3 studies (two perfusate) met the criteria of 'good' quality and only 12 were published since 2000. Perfusate lactate dehydrogenase, glutathione-S-transferase (GST) and aspartate transaminase were all found to be significantly associated with delayed graft function in a majority of their respective studies (6/9, 4/6 and 2/2 studies, respectively). Urine neutrophil gelatinase-associated lipocalin, GST, Trolox-equivalent antioxidant capacity and kidney injury molecule-1 were found to be significantly associated with allograft outcomes in single studies that examined diverse end points. Conclusion. Higher quality studies are needed to investigate modern kidney injury biomarkers, to validate novel biomarkers in larger donor populations and to determine the incremental predictive value of biomarkers over traditional clinical variables. Published by Oxford University Press on behalf of ERA-EDTA 2012. 2012
KW - biomarkers
KW - deceased donors
KW - delayed graft function
KW - kidney transplantation
UR - http://www.scopus.com/inward/record.url?scp=84864614153&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864614153&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfr806
DO - 10.1093/ndt/gfr806
M3 - Article
C2 - 22498916
AN - SCOPUS:84864614153
VL - 27
SP - 3305
EP - 3314
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 8
ER -