decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary

Ting Xie, Allan C. Spradling

Research output: Contribution to journalArticle

Abstract

Stem cells are thought to occupy special local environments, or niches, established by neighboring cells that give them the capability for self- renewal. Each ovariole in the Drosophila ovary contains two germline stem cells surrounded by a group of differentiated somatic cells that express hedgehog and wingless. Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to maintain female germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differentiation. Conversely, mutations in dpp or its receptor (saxophone) accelerate stem cell loss and retard stem cell division. We constructed mutant germline stem cell clones to show that the dpp signal is directly received by germline stem cells. Thus, dpp signaling helps define a niche that controls germline stem cell proliferation.

Original languageEnglish (US)
Pages (from-to)251-260
Number of pages10
JournalCell
Volume94
Issue number2
DOIs
StatePublished - Jul 24 1998
Externally publishedYes

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Stem cells
Drosophila
Ovary
Stem Cells
Maintenance
Hedgehogs
Cell proliferation
Cell Division
Cell Differentiation
Clone Cells
Cell Proliferation
Mutation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. / Xie, Ting; Spradling, Allan C.

In: Cell, Vol. 94, No. 2, 24.07.1998, p. 251-260.

Research output: Contribution to journalArticle

Xie, Ting ; Spradling, Allan C. / decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. In: Cell. 1998 ; Vol. 94, No. 2. pp. 251-260.
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