Death from within: Apoptosis and the secretory pathway

Rebecca S. Maag, Stuart W. Hicks, Carolyn E Machamer

Research output: Contribution to journalArticle

Abstract

Recent studies have highlighted the importance of the secretory pathway in stress-induced apoptotic signaling. Sensing stress at the endoplasmic reticulum and Golgi might first trigger recovery mechanisms, followed by apoptosis if repair is unsuccessful. Cleavage of endoplasmic-reticulum- or Golgi-resident proteins can signal repair or apoptosis and promote organelle disassembly during apoptosis. Initiation of apoptosis from the secretory pathway requires components of the death machinery localized to these membranes. Extensive trafficking between compartments of the secretory pathway might allow the cell to integrate signals and to determine the proper response to a particular stress.

Original languageEnglish (US)
Pages (from-to)456-461
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume15
Issue number4
DOIs
StatePublished - Aug 2003

Fingerprint

Secretory Pathway
Apoptosis
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Organelles
Membranes
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Death from within : Apoptosis and the secretory pathway. / Maag, Rebecca S.; Hicks, Stuart W.; Machamer, Carolyn E.

In: Current Opinion in Cell Biology, Vol. 15, No. 4, 08.2003, p. 456-461.

Research output: Contribution to journalArticle

Maag, Rebecca S. ; Hicks, Stuart W. ; Machamer, Carolyn E. / Death from within : Apoptosis and the secretory pathway. In: Current Opinion in Cell Biology. 2003 ; Vol. 15, No. 4. pp. 456-461.
@article{9a06e3518b07483fb4a77f73602cffbc,
title = "Death from within: Apoptosis and the secretory pathway",
abstract = "Recent studies have highlighted the importance of the secretory pathway in stress-induced apoptotic signaling. Sensing stress at the endoplasmic reticulum and Golgi might first trigger recovery mechanisms, followed by apoptosis if repair is unsuccessful. Cleavage of endoplasmic-reticulum- or Golgi-resident proteins can signal repair or apoptosis and promote organelle disassembly during apoptosis. Initiation of apoptosis from the secretory pathway requires components of the death machinery localized to these membranes. Extensive trafficking between compartments of the secretory pathway might allow the cell to integrate signals and to determine the proper response to a particular stress.",
author = "Maag, {Rebecca S.} and Hicks, {Stuart W.} and Machamer, {Carolyn E}",
year = "2003",
month = "8",
doi = "10.1016/S0955-0674(03)00075-9",
language = "English (US)",
volume = "15",
pages = "456--461",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Death from within

T2 - Apoptosis and the secretory pathway

AU - Maag, Rebecca S.

AU - Hicks, Stuart W.

AU - Machamer, Carolyn E

PY - 2003/8

Y1 - 2003/8

N2 - Recent studies have highlighted the importance of the secretory pathway in stress-induced apoptotic signaling. Sensing stress at the endoplasmic reticulum and Golgi might first trigger recovery mechanisms, followed by apoptosis if repair is unsuccessful. Cleavage of endoplasmic-reticulum- or Golgi-resident proteins can signal repair or apoptosis and promote organelle disassembly during apoptosis. Initiation of apoptosis from the secretory pathway requires components of the death machinery localized to these membranes. Extensive trafficking between compartments of the secretory pathway might allow the cell to integrate signals and to determine the proper response to a particular stress.

AB - Recent studies have highlighted the importance of the secretory pathway in stress-induced apoptotic signaling. Sensing stress at the endoplasmic reticulum and Golgi might first trigger recovery mechanisms, followed by apoptosis if repair is unsuccessful. Cleavage of endoplasmic-reticulum- or Golgi-resident proteins can signal repair or apoptosis and promote organelle disassembly during apoptosis. Initiation of apoptosis from the secretory pathway requires components of the death machinery localized to these membranes. Extensive trafficking between compartments of the secretory pathway might allow the cell to integrate signals and to determine the proper response to a particular stress.

UR - http://www.scopus.com/inward/record.url?scp=0042266400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042266400&partnerID=8YFLogxK

U2 - 10.1016/S0955-0674(03)00075-9

DO - 10.1016/S0955-0674(03)00075-9

M3 - Article

C2 - 12892786

AN - SCOPUS:0042266400

VL - 15

SP - 456

EP - 461

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 4

ER -