Dear old dad.

Rivka L. Glaser, Ethylin Wang Jabs

Research output: Contribution to journalArticle

Abstract

The origin and frequency of spontaneous mutations that occur with age in humans have been a topic of intense discussion. The mechanisms by which spontaneous mutations arise depend on the parental germ line in which a mutation occurs. In general, paternal mutations are more likely than maternal mutations to be base substitutions. This is likely due to the larger number of germ cell divisions in spermatogenesis than in oogenesis. Maternal mutations are more often chromosomal abnormalities. Advanced parental age seems to influence some mutations, although it is not a factor in the creation of others. In this review, we focus on patterns of paternal bias and age dependence of mutations in different genetic disorders, and the various mechanisms by which these mutations arise. We also discuss recent data on age and the frequency of these mutations in the human male germ line and the impact of these data on this field of research.

Original languageEnglish (US)
JournalScience of aging knowledge environment : SAGE KE
Volume2004
Issue number3
StatePublished - 2004
Externally publishedYes

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Mutation
Germ Cells
Mutation Rate
Paternal Age
Mothers
Oogenesis
Inborn Genetic Diseases
Spermatogenesis
Chromosome Aberrations
Cell Division
Parents
Research

Cite this

Glaser, R. L., & Jabs, E. W. (2004). Dear old dad. Science of aging knowledge environment : SAGE KE, 2004(3).

Dear old dad. / Glaser, Rivka L.; Jabs, Ethylin Wang.

In: Science of aging knowledge environment : SAGE KE, Vol. 2004, No. 3, 2004.

Research output: Contribution to journalArticle

Glaser, RL & Jabs, EW 2004, 'Dear old dad.', Science of aging knowledge environment : SAGE KE, vol. 2004, no. 3.
Glaser, Rivka L. ; Jabs, Ethylin Wang. / Dear old dad. In: Science of aging knowledge environment : SAGE KE. 2004 ; Vol. 2004, No. 3.
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