Deactivation of cholera toxin by ganglioside

William E. Van Heyningen, Charles C.J. Carpenter, Nathaniel F. Pierce, William B. Greenough

Research output: Contribution to journalArticlepeer-review

Abstract

The toxin of Vibrio cholerae increases the activity of adenyl cyclase in cell membranes. Interaction between intestinal cell membranes and the toxin of V. cholerae leads to the profuse secretory activity seen in choleraic diarrhea. Lipid-containing extracts of various tissues were found to inhibit the activity of cholera toxin; the highest amounts of the inhibitory factor were found in brain. The inhibitor has properties similar to those of gangliosides. The effect of cholera toxin on intestinal loops of rabbits and epididymal fat cells of rats was neutralized by purified ganglioside. The results suggested that fixation to gangliosides may play a role in the binding of cholera toxin to cell membranes.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalJournal of Infectious Diseases
Volume124
Issue number4
DOIs
StatePublished - Oct 1971

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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