De novo neuroendocrine features in prostate cancer

Eman Abdulfatah, Samson W. Fine, Tamara L. Lotan, Rohit Mehra

Research output: Contribution to journalReview articlepeer-review


Neuroendocrine tumors of the prostate are rare and encompass a group of entities that are classified based on a combination of morphological and immunohistochemical features. Despite the 2016 World Health Organization classification of prostatic neuroendocrine tumors, variants have been reported that do not fit well in the categorization scheme. While the majority of these tumors arise in the setting of castration-resistant prostate cancer (postandrogen deprivation therapy), de novo cases may occur. In this review, we highlight the most significant pathological and immunohistochemical features, emerging biomarkers, and molecular features of such tumors.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalHuman pathology
StatePublished - Sep 2022


  • De novo
  • Neuroendocrine
  • Proproliferative
  • Prostate
  • Transdifferentiation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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