De Novo Coding Variants Are Strongly Associated with Tourette Disorder

Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG), Tourette Syndrome Association International Consortium for Genetics (TSAICG)

Research output: Contribution to journalArticle

Abstract

Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative Genetics cohort and a replication sample of 186 trios from the Tourette Syndrome Association International Consortium on Genetics (511 total). We observe strong and consistent evidence for the contribution of de novo likely gene-disrupting (LGD) variants (rate ratio [RR] 2.32, p = 0.002). Additionally, de novo damaging variants (LGD and probably damaging missense) are overrepresented in probands (RR 1.37, p = 0.003). We identify four likely risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1 (fibronectin 1). Overall, we estimate that de novo damaging variants in approximately 400 genes contribute risk in 12% of clinical cases. Video Abstract [Figure presented]

Original languageEnglish (US)
Pages (from-to)486-499.e9
JournalNeuron
Volume94
Issue number3
DOIs
StatePublished - May 3 2017

Fingerprint

Tourette Syndrome
Exome
Genes
Genetic Association Studies
Cadherins
Fibronectins
Epidermal Growth Factor

Keywords

  • de novo variants
  • gene discovery
  • TIC Genetics
  • Tourette disorder
  • Tourette syndrome
  • TSAICG
  • whole-exome sequencing

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG), & Tourette Syndrome Association International Consortium for Genetics (TSAICG) (2017). De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron, 94(3), 486-499.e9. https://doi.org/10.1016/j.neuron.2017.04.024

De Novo Coding Variants Are Strongly Associated with Tourette Disorder. / Tourette International Collaborative Genetics (TIC Genetics); Tourette Syndrome Association International Consortium for Genetics (TSAICG); Tourette Syndrome Association International Consortium for Genetics (TSAICG).

In: Neuron, Vol. 94, No. 3, 03.05.2017, p. 486-499.e9.

Research output: Contribution to journalArticle

Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG) & Tourette Syndrome Association International Consortium for Genetics (TSAICG) 2017, 'De Novo Coding Variants Are Strongly Associated with Tourette Disorder', Neuron, vol. 94, no. 3, pp. 486-499.e9. https://doi.org/10.1016/j.neuron.2017.04.024
Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG), Tourette Syndrome Association International Consortium for Genetics (TSAICG). De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron. 2017 May 3;94(3):486-499.e9. https://doi.org/10.1016/j.neuron.2017.04.024
Tourette International Collaborative Genetics (TIC Genetics) ; Tourette Syndrome Association International Consortium for Genetics (TSAICG) ; Tourette Syndrome Association International Consortium for Genetics (TSAICG). / De Novo Coding Variants Are Strongly Associated with Tourette Disorder. In: Neuron. 2017 ; Vol. 94, No. 3. pp. 486-499.e9.
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AU - Smith, Louw

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AU - Samocha, Kaitlin E.

AU - Abdulkadir, Mohamed

AU - Bohnenpoll, Julia

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AU - Brown, Lawrence W.

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N2 - Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative Genetics cohort and a replication sample of 186 trios from the Tourette Syndrome Association International Consortium on Genetics (511 total). We observe strong and consistent evidence for the contribution of de novo likely gene-disrupting (LGD) variants (rate ratio [RR] 2.32, p = 0.002). Additionally, de novo damaging variants (LGD and probably damaging missense) are overrepresented in probands (RR 1.37, p = 0.003). We identify four likely risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1 (fibronectin 1). Overall, we estimate that de novo damaging variants in approximately 400 genes contribute risk in 12% of clinical cases. Video Abstract [Figure presented]

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