Darwinian evolution in the genealogy of haemoglobin

Morris Goodman, G. William Moore, Genji Matsuda

Research output: Contribution to journalArticle

Abstract

Frequencies of mutations between reconstructed ancestor and descendant sequences of codons for metazoan globin chains show that natural selection guided protein evolution. Mutations which improved haemoglobin function were accepted at an accelerated rate in the first vertebrates. Rates decelerated after functional opportunities had been exploited.

Original languageEnglish (US)
Pages (from-to)603-608
Number of pages6
JournalNature
Volume253
Issue number5493
DOIs
StatePublished - 1975
Externally publishedYes

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    Goodman, M., Moore, G. W., & Matsuda, G. (1975). Darwinian evolution in the genealogy of haemoglobin. Nature, 253(5493), 603-608. https://doi.org/10.1038/253603a0