Darwinian evolution in the genealogy of haemoglobin

Morris Goodman, G. William Moore, Genji Matsuda

Research output: Contribution to journalArticle

Abstract

Frequencies of mutations between reconstructed ancestor and descendant sequences of codons for metazoan globin chains show that natural selection guided protein evolution. Mutations which improved haemoglobin function were accepted at an accelerated rate in the first vertebrates. Rates decelerated after functional opportunities had been exploited.

Original languageEnglish (US)
Pages (from-to)603-608
Number of pages6
JournalNature
Volume253
Issue number5493
DOIs
StatePublished - 1975
Externally publishedYes

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Genealogy and Heraldry
Globins
Genetic Selection
Mutation Rate
Codon
Vertebrates
Hemoglobins
Mutation
Proteins

ASJC Scopus subject areas

  • General

Cite this

Goodman, M., Moore, G. W., & Matsuda, G. (1975). Darwinian evolution in the genealogy of haemoglobin. Nature, 253(5493), 603-608. https://doi.org/10.1038/253603a0

Darwinian evolution in the genealogy of haemoglobin. / Goodman, Morris; Moore, G. William; Matsuda, Genji.

In: Nature, Vol. 253, No. 5493, 1975, p. 603-608.

Research output: Contribution to journalArticle

Goodman, M, Moore, GW & Matsuda, G 1975, 'Darwinian evolution in the genealogy of haemoglobin', Nature, vol. 253, no. 5493, pp. 603-608. https://doi.org/10.1038/253603a0
Goodman M, Moore GW, Matsuda G. Darwinian evolution in the genealogy of haemoglobin. Nature. 1975;253(5493):603-608. https://doi.org/10.1038/253603a0
Goodman, Morris ; Moore, G. William ; Matsuda, Genji. / Darwinian evolution in the genealogy of haemoglobin. In: Nature. 1975 ; Vol. 253, No. 5493. pp. 603-608.
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