Darwinian evolution in the genealogy of haemoglobin

Morris Goodman; G. William Moore; Genji Matsuda

doi:10.1038/253603a0

Darwinian evolution in the genealogy of haemoglobin

Morris Goodman, G. William Moore, Genji Matsuda

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Abstract

Frequencies of mutations between reconstructed ancestor and descendant sequences of codons for metazoan globin chains show that natural selection guided protein evolution. Mutations which improved haemoglobin function were accepted at an accelerated rate in the first vertebrates. Rates decelerated after functional opportunities had been exploited.

Original language	English (US)
Pages (from-to)	603-608
Number of pages	6
Journal	Nature
Volume	253
Issue number	5493
DOIs	https://doi.org/10.1038/253603a0
State	Published - 1975
Externally published	Yes

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title = "Darwinian evolution in the genealogy of haemoglobin",

abstract = "Frequencies of mutations between reconstructed ancestor and descendant sequences of codons for metazoan globin chains show that natural selection guided protein evolution. Mutations which improved haemoglobin function were accepted at an accelerated rate in the first vertebrates. Rates decelerated after functional opportunities had been exploited.",

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Darwinian evolution in the genealogy of haemoglobin

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