@article{aac9bc0d9da8442bb3a3a57d02f10f53,
title = "Darkroom prone provocative testing in primary angle closure suspects and those with open angles",
abstract = "Purpose To describe the results of darkroom prone provocative testing (DRPPT) in primary angle closure suspects (PACS) and to compare the findings to controls with open angles. Methods 889 subjects with PACS in the Zhongshan Angle Closure Prevention Trial (a randomised controlled trial to compare prophylactic laser iridotomy to no treatment in PACS) and 89 with open angles in the 5-year follow-up of Liwan Eye Study were placed in a darkroom face down for 15 min. Intraocular pressure (IOP) was measured immediately before and after DRPPT. Results PACS participants were of similar age than controls (59.3 vs 60.5), more often female (82.9% vs 58.4%) and had lower IOP (14.3 vs 15.2 mm Hg). The average IOP increases after DRPPT was 4.3±3 mm Hg in PACS and 5.2±2.8 in controls (p<0.05). 20.5% of controls and 13.9 % of those with PACS developed an IOP spike ≥8 mm Hg after DRPPT (p<0.05). Among PACS, 15.8 % of those with all four quadrants closed had an IOP elevation of ≥ 8 mm Hg as opposed to 10.0%-12.4 % with two or three closed quadrants (p<0.05). DRPPT failed to predict who would reach a clinical trial endpoint over 6-year follow-up of those with PACS. Conclusions A modified DRPPT failed to separate PACS from those with open angle. Although the test resulted in greater IOP elevation among those PACS participants with all four quadrants closed than in those with two or three closed quadrants, it did not offer any insight into the risk of developing acute or chronic angle closure disease over 6-year follow-up.",
keywords = "glaucoma",
author = "Friedman, {David S.} and Chang, {Dolly Shuo Teh} and Yuzhen Jiang and Shengsong Huang and Xiangbin Kong and Beatriz Munoz and Tin Aung and Foster, {Paul J.} and Mingguang He",
note = "Funding Information: This work is supported by the Fight for Sight (grant no. 1655) (United Kingdom), the Sun Yat-sen University 5010 Project Fund (grant no. 2007033) (China), the National Natural Science Foundation of China (grant no. 81420108008) (China) and Fundamental Research Funds of the State Key Laboratory in Ophthalmology (China). Professor He receives support from the University of Melbourne Research at Melbourne Accelerator Program Professorship. The Centre for Eye Research Australia receives operational infrastructural support from the Victorian government. Dr. Jiang and Professor Foster supported by a grant from the British Council for Prevention of Blindness (UK). Professor Foster received additional support from the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital, London, United Kingdom (NIHR-BRC2 009; Moorfields/UCL-IOO), Special Trustees of Moorfields Eye Hospital (since renamed Moorfields Eye Charity) and the Richard Desmond Charitable Foundation (via Fight for Sight UK). These funding sources did not play any role in the design and conduct of the study; in the collection, management, analysis or interpretation of the data; or in the preparation, review, approval of the manuscript, or decision to submit the manuscript for publication. Funding Information: Funding This work is supported by the Fight for Sight (grant no. 1655) (United Kingdom), the Sun Yat-sen University 5010 Project Fund (grant no. 2007033) (China), the National Natural Science Foundation of China (grant no. 81420108008) (China) and Fundamental Research Funds of the State Key Laboratory in Ophthalmology (China). Professor He receives support from the University of Melbourne Research at Melbourne Accelerator Program Professorship. The Centre for Eye Research Australia receives operational infrastructural support from the Victorian government. Dr. Jiang and Professor Foster supported by a grant from the British Council for Prevention of Blindness (UK). Professor Foster received additional support from the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital, London, United Kingdom (NIHR-BRC2 009; Moorfields/UCL-IOO), Special Trustees of Moorfields Eye Hospital (since renamed Moorfields Eye Charity) and the Richard Desmond Charitable Foundation (via Fight for Sight UK). These funding sources did not play any role in the design and conduct of the study; in the collection, management, analysis or interpretation of the data; or in the preparation, review, approval of the manuscript, or decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = dec,
day = "1",
doi = "10.1136/bjophthalmol-2018-313362",
language = "English (US)",
volume = "103",
pages = "1834--1839",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "12",
}