Dark rearing alters the development of GABAergic transmission in visual cortex

Bernardo Morales, Se Young Choi, Alfredo Kirkwood

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the role of sensory experience in the maturation of GABAergic circuits in the rat visual cortex. Between the time at which the eyes first open and the end of the critical period for experience-dependent plasticity, the total GABAergic input converging into layer II/III pyramidal cells increases threefold. We propose that this increase reflects changes in the number of quanta released by presynaptic axons. Here, we show that the developmental increase in GABAergic input is prevented in animals deprived of light since birth but not in animals deprived of light after a period of normal experience. Thus, sensory experience appears to play a permissive role in the maturation of intracortical GABAergic circuits.

Original languageEnglish (US)
Pages (from-to)8084-8090
Number of pages7
JournalJournal of Neuroscience
Volume22
Issue number18
DOIs
StatePublished - Sep 15 2002

Keywords

  • Critical period
  • EPSC
  • IPSC
  • Plasticity
  • Sensory experience
  • Synaptic inhibition

ASJC Scopus subject areas

  • Neuroscience(all)

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