d‐Arg[Hyp3‐Thi5‐d‐Tic7‐Tic8]‐bradykinin, a potent antagonist of smooth muscle BK2 receptors and BK3 receptors

S. G. Farmer, R. M. Burch, D. J. Kyle, J. A. Martin, S. N. Meeker, J. Togo

Research output: Contribution to journalArticlepeer-review

Abstract

d‐Arg[Hyp3‐Thi5‐d‐Tic7‐Tic8]‐bradykinin (NPC 16731) inhibited bradykinin (BK) binding and BK‐induced contraction in guinea‐pig ileum, being markedly more potent than d‐Phe7‐BK analogues as a BK2 receptor antagonist. In isolated trachea NPC 16731, unlike other BK2 antagonists, inhibited BK binding and BK‐induced contraction, and 45Ca2+ efflux in tracheal smooth muscle cells. That NPC 16731 potently inhibits BK effects in trachea provides further evidence for the existence of the airway BK3 receptor. 1991 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)785-787
Number of pages3
JournalBritish Journal of Pharmacology
Volume102
Issue number4
DOIs
StatePublished - Apr 1991
Externally publishedYes

Keywords

  • BK receptor
  • BK receptor
  • Bradykinin
  • Ca efflux
  • antagonist
  • bradykinin binding
  • contraction
  • ileum
  • smooth muscle
  • trachea

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'd‐Arg[Hyp<sup>3</sup>‐Thi<sup>5</sup>‐d‐Tic<sup>7</sup>‐Tic<sup>8</sup>]‐bradykinin, a potent antagonist of smooth muscle BK<sub>2</sub> receptors and BK<sub>3</sub> receptors'. Together they form a unique fingerprint.

Cite this