Daptomycin therapy failure in an adolescent with methicillin-resistant staphylococcus aureus bacteremia

Lara M. Jacobson; Aaron M. Milstone; Jonathan Zenilman; Karen C. Carroll; Ravit Arav-Boger

doi:10.1097/INF.0b013e3181927891

Daptomycin therapy failure in an adolescent with methicillin-resistant staphylococcus aureus bacteremia

Lara M. Jacobson, Aaron M. Milstone, Jonathan Zenilman, Karen C. Carroll, Ravit Arav-Boger

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Daptomycin is a Food and Drug Administration-approved alternative to vancomycin for the treatment of serious methicillin-resistant Staphylococcus aureus infections in adults. Treatment failure with daptomycin is increasingly reported in adults, but data in children are limited. We report an adolescent patient with severe burn injuries who had persistent methicillin-resistant Staphylococcus aureus bacteremia and rapidly developed nonsusceptibility to daptomycin. We review the relevant literature.

Original language	English (US)
Pages (from-to)	445-447
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	28
Issue number	5
DOIs	https://doi.org/10.1097/INF.0b013e3181927891
State	Published - May 2009

Keywords

Daptomycin
MRSA
Nonsusceptible
Resistance
Staphylococcus aureus

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0b013e3181927891

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abstract = "Daptomycin is a Food and Drug Administration-approved alternative to vancomycin for the treatment of serious methicillin-resistant Staphylococcus aureus infections in adults. Treatment failure with daptomycin is increasingly reported in adults, but data in children are limited. We report an adolescent patient with severe burn injuries who had persistent methicillin-resistant Staphylococcus aureus bacteremia and rapidly developed nonsusceptibility to daptomycin. We review the relevant literature.",

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AU - Carroll, Karen C.

AU - Arav-Boger, Ravit

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AB - Daptomycin is a Food and Drug Administration-approved alternative to vancomycin for the treatment of serious methicillin-resistant Staphylococcus aureus infections in adults. Treatment failure with daptomycin is increasingly reported in adults, but data in children are limited. We report an adolescent patient with severe burn injuries who had persistent methicillin-resistant Staphylococcus aureus bacteremia and rapidly developed nonsusceptibility to daptomycin. We review the relevant literature.

KW - Daptomycin

KW - MRSA

KW - Nonsusceptible

KW - Resistance

KW - Staphylococcus aureus

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Daptomycin therapy failure in an adolescent with methicillin-resistant staphylococcus aureus bacteremia

Abstract

Keywords

ASJC Scopus subject areas

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