Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits

Michelle C.D. Bridi, Fang Jiao Zong, Xia Min, Nancy Luo, Trinh Tran, Jiaqian Qiu, Daniel Severin, Xue Ting Zhang, Guanglin Wang, Zheng Jiang Zhu, Kai Wen He, Alfredo Kirkwood

Research output: Contribution to journalArticle

Abstract

A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and altered in many neurological disorders. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-h day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that, in pyramidal cells of visual and prefrontal cortices and hippocampal CA1, synaptic inhibition also changes over the 24-h light/dark cycle but, surprisingly, in the opposite direction of synaptic excitation. Inhibition is upregulated in the visual cortex during the light phase in a sleep-dependent manner. In the visual cortex, these changes in the E/I balance occurred in feedback, but not feedforward, circuits. These observations open new and interesting questions on the function and regulation of the E/I balance.

Original languageEnglish (US)
Pages (from-to)621-629.e4
JournalNeuron
Volume105
Issue number4
DOIs
StatePublished - Feb 19 2020

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bridi, M. C. D., Zong, F. J., Min, X., Luo, N., Tran, T., Qiu, J., Severin, D., Zhang, X. T., Wang, G., Zhu, Z. J., He, K. W., & Kirkwood, A. (2020). Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits. Neuron, 105(4), 621-629.e4. https://doi.org/10.1016/j.neuron.2019.11.011