TY - JOUR
T1 - Daily cannabis use in adolescents who smoke tobacco is associated with altered late-stage feedback processing
T2 - A high-density electrical mapping study
AU - Morie, Kristen P.
AU - Wu, Jia
AU - Potenza, Marc N.
AU - Krishnan-Sarin, Suchitra
AU - Mayes, Linda C.
AU - Hammond, Christopher J.
AU - Crowley, Michael J.
N1 - Funding Information:
Funding for this work included National Institute of Health grants K01DA042937 , K01 DA034125 (MJC) , T32 MH018268 (MJC) , P50 DA09241 , UL1-DE19586 , RL1 AA017539 , R01 DA006025 , R01 DA017863 , K05 DA020091 ; T32 DA007238 and R21 DA030665 . KPM receives support from MH018268-31 and from K01DA042937 . MNP was supported by R01 DA035058 , R01 DA039136 , the National Center for Responsible Gaming , the Connecticut Council on Problem Gambling, and the Connecticut Department of Mental Health and Addiction Services. Beyond funding, the funding agencies had no further role in the writing of the report or in the decision to submit the paper for publication. This work was funded in part by the State of Connecticut, Department of Mental Health and Addiction Services, but this publication does not express the views of the Department of Mental Health and Addiction Services or the State of Connecticut. The views and opinions expressed are those of the authors.
Publisher Copyright:
© 2021
PY - 2021/7
Y1 - 2021/7
N2 - Impairments in feedback processing, often associated with risk-taking behavior, may have implications for development of substance abuse in adolescents. The most commonly used substances by adolescents include tobacco and cannabis, with some individuals using both substances, potentially heightening risk. Our objective was to examine feedback processing and impulsivity in adolescents who smoke cigarettes and use cannabis daily (N = 21), comparing them with adolescents who smoke cigarettes daily and use cannabis occasionally (N = 18) and non-smoking (N = 27) adolescents. To do this, the Balloon Analog Risk Task (BART) with concurrent EEG was used to measure risk-related feedback processing, and impulsivity was measured using the Barratt's impulsiveness scale (BIS-11). It was found that adolescent daily tobacco/cannabis smoking was associated with higher BIS-11 scores, shortened feedback-related-negativity (FRN) latencies and reduced P300 amplitudes. In addition, FRN latencies during win conditions were inversely associated with tobacco-use severity, indicated by scores on the Fagerstrom Test for Nicotine Dependence (FTND), and with BIS-11 scores. Adolescents with concurrent tobacco and cannabis use show altered feedback processing and higher impulsivity. Future work should disentangle whether the effect reflects risk, consequences of use or both.
AB - Impairments in feedback processing, often associated with risk-taking behavior, may have implications for development of substance abuse in adolescents. The most commonly used substances by adolescents include tobacco and cannabis, with some individuals using both substances, potentially heightening risk. Our objective was to examine feedback processing and impulsivity in adolescents who smoke cigarettes and use cannabis daily (N = 21), comparing them with adolescents who smoke cigarettes daily and use cannabis occasionally (N = 18) and non-smoking (N = 27) adolescents. To do this, the Balloon Analog Risk Task (BART) with concurrent EEG was used to measure risk-related feedback processing, and impulsivity was measured using the Barratt's impulsiveness scale (BIS-11). It was found that adolescent daily tobacco/cannabis smoking was associated with higher BIS-11 scores, shortened feedback-related-negativity (FRN) latencies and reduced P300 amplitudes. In addition, FRN latencies during win conditions were inversely associated with tobacco-use severity, indicated by scores on the Fagerstrom Test for Nicotine Dependence (FTND), and with BIS-11 scores. Adolescents with concurrent tobacco and cannabis use show altered feedback processing and higher impulsivity. Future work should disentangle whether the effect reflects risk, consequences of use or both.
KW - Addictive behaviors
KW - Adolescents
KW - Cannabis
KW - Electroencephalography
KW - Feedback processing
KW - Impulsivity
KW - Risk-taking
KW - Tobacco
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U2 - 10.1016/j.jpsychires.2021.05.022
DO - 10.1016/j.jpsychires.2021.05.022
M3 - Article
C2 - 34052575
AN - SCOPUS:85106655631
VL - 139
SP - 82
EP - 90
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
ER -