D919G polymorphism of methionine synthase gene is associated with blood pressure response to benzepril in Chinese hypertensive patients

Yan Zhang, Minmin Zhang, Tianhua Niu, Xin Xu, Guoying Zhu, Yong Huo, Changzhong Chen, Xiaobin Wang, Houxun Xing, Shaojie Peng, Aiqun Huang, Xiumei Hong, Xiping Xu

Research output: Contribution to journalArticle

Abstract

Individual variation in drug response is considered to have multiple origins arising from interactions among susceptible genes and environmental factors. A total of 726 hypertensive patients who took benazepril 10 mg once a day for 15 days and their families from Huoqiu county of Anhui Province, China, were used to study the association between D919G polymorphism of methionine synthase (MTR) gene and the antihypertensive effect of this angiotensin- converting enzyme inhibitor. Compared to the 919D allele, both population-based (P = 0.010) and family-based association tests (additive model P = 0.018, dominant model P = 0.025) demonstrated that the 919G allele was associated with a significantly less diastolic blood pressure reduction. No significant association was found between the extent of systolic blood pressure reduction and benazepril therapy. Our finding suggests that the D919G polymorphism of the MTR gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril therapy in hypertensive patients of Anhui Province, China.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalJournal of Human Genetics
Volume49
Issue number6
StatePublished - 2004
Externally publishedYes

Fingerprint

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Blood Pressure
Antihypertensive Agents
Genes
China
Alleles
Genetic Markers
Angiotensin-Converting Enzyme Inhibitors
Therapeutics
Pharmaceutical Preparations
Population
benazepril

Keywords

  • Benazepril
  • Blood pressure
  • Hypertension
  • Methionine synthase
  • Polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

D919G polymorphism of methionine synthase gene is associated with blood pressure response to benzepril in Chinese hypertensive patients. / Zhang, Yan; Zhang, Minmin; Niu, Tianhua; Xu, Xin; Zhu, Guoying; Huo, Yong; Chen, Changzhong; Wang, Xiaobin; Xing, Houxun; Peng, Shaojie; Huang, Aiqun; Hong, Xiumei; Xu, Xiping.

In: Journal of Human Genetics, Vol. 49, No. 6, 2004, p. 296-301.

Research output: Contribution to journalArticle

Zhang, Y, Zhang, M, Niu, T, Xu, X, Zhu, G, Huo, Y, Chen, C, Wang, X, Xing, H, Peng, S, Huang, A, Hong, X & Xu, X 2004, 'D919G polymorphism of methionine synthase gene is associated with blood pressure response to benzepril in Chinese hypertensive patients', Journal of Human Genetics, vol. 49, no. 6, pp. 296-301.
Zhang, Yan ; Zhang, Minmin ; Niu, Tianhua ; Xu, Xin ; Zhu, Guoying ; Huo, Yong ; Chen, Changzhong ; Wang, Xiaobin ; Xing, Houxun ; Peng, Shaojie ; Huang, Aiqun ; Hong, Xiumei ; Xu, Xiping. / D919G polymorphism of methionine synthase gene is associated with blood pressure response to benzepril in Chinese hypertensive patients. In: Journal of Human Genetics. 2004 ; Vol. 49, No. 6. pp. 296-301.
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AU - Zhang, Yan

AU - Zhang, Minmin

AU - Niu, Tianhua

AU - Xu, Xin

AU - Zhu, Guoying

AU - Huo, Yong

AU - Chen, Changzhong

AU - Wang, Xiaobin

AU - Xing, Houxun

AU - Peng, Shaojie

AU - Huang, Aiqun

AU - Hong, Xiumei

AU - Xu, Xiping

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AB - Individual variation in drug response is considered to have multiple origins arising from interactions among susceptible genes and environmental factors. A total of 726 hypertensive patients who took benazepril 10 mg once a day for 15 days and their families from Huoqiu county of Anhui Province, China, were used to study the association between D919G polymorphism of methionine synthase (MTR) gene and the antihypertensive effect of this angiotensin- converting enzyme inhibitor. Compared to the 919D allele, both population-based (P = 0.010) and family-based association tests (additive model P = 0.018, dominant model P = 0.025) demonstrated that the 919G allele was associated with a significantly less diastolic blood pressure reduction. No significant association was found between the extent of systolic blood pressure reduction and benazepril therapy. Our finding suggests that the D919G polymorphism of the MTR gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril therapy in hypertensive patients of Anhui Province, China.

KW - Benazepril

KW - Blood pressure

KW - Hypertension

KW - Methionine synthase

KW - Polymorphism

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