D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21

Andrew C. Warren, Michael B. Petersen, Wim Van Hul, Melvin G. McInnis, Christine Van Broeckhoven, Tara K. Cox, Aravinda Chakravarti, Stylianos E. Antonarakis

Research output: Contribution to journalArticle

Abstract

A plasmid, AWZ1, that contained a dinucleotide (GT)n repeat was identified from a chromosome 21-specific genomic library. When amplified by PCR from human genomic DNA, the repeat length was highly polymorphic between individuals; its location, D21S215, was mapped in the CEPH pedigrees by linkage analysis to the pericentromeric region of chromosome 21. It is the closest polymorphic marker to alphoid sequences on this chromosome.

Original languageEnglish (US)
Pages (from-to)1365-1367
Number of pages3
JournalGenomics
Volume13
Issue number4
DOIs
StatePublished - Aug 1992

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ASJC Scopus subject areas

  • Genetics

Cite this

Warren, A. C., Petersen, M. B., Van Hul, W., McInnis, M. G., Van Broeckhoven, C., Cox, T. K., Chakravarti, A., & Antonarakis, S. E. (1992). D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21. Genomics, 13(4), 1365-1367. https://doi.org/10.1016/0888-7543(92)90072-Z