TY - JOUR
T1 - D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21
AU - Warren, Andrew C.
AU - Petersen, Michael B.
AU - Van Hul, Wim
AU - McInnis, Melvin G.
AU - Van Broeckhoven, Christine
AU - Cox, Tara K.
AU - Chakravarti, Aravinda
AU - Antonarakis, Stylianos E.
N1 - Funding Information:
A.C.W. is grateful for support from the Alzheimer’s Association. S.E.A. was supported by NIH Grants HD24605 and HG00373 and a DOE Grant FG02-89ER60857. M.B.P. was supported by grants from Novo’s Foundation, the Danish Foundation for the Advancement of Medical Science, and the Danish Human Genome Research Program (5.18.10.03). C.V.B. is a research associate of the National Fund for Scientific Research (NFSR) and is supported by the National Incentive Program on Life Sciences, The Flemish Biotechnology Program, and Innogenetics Inc., Belgium. We thank Dr. David Patterson for providing the hybrid cell lines.
PY - 1992/8
Y1 - 1992/8
N2 - A plasmid, AWZ1, that contained a dinucleotide (GT)n repeat was identified from a chromosome 21-specific genomic library. When amplified by PCR from human genomic DNA, the repeat length was highly polymorphic between individuals; its location, D21S215, was mapped in the CEPH pedigrees by linkage analysis to the pericentromeric region of chromosome 21. It is the closest polymorphic marker to alphoid sequences on this chromosome.
AB - A plasmid, AWZ1, that contained a dinucleotide (GT)n repeat was identified from a chromosome 21-specific genomic library. When amplified by PCR from human genomic DNA, the repeat length was highly polymorphic between individuals; its location, D21S215, was mapped in the CEPH pedigrees by linkage analysis to the pericentromeric region of chromosome 21. It is the closest polymorphic marker to alphoid sequences on this chromosome.
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U2 - 10.1016/0888-7543(92)90072-Z
DO - 10.1016/0888-7543(92)90072-Z
M3 - Article
C2 - 1505976
AN - SCOPUS:0026768544
SN - 0888-7543
VL - 13
SP - 1365
EP - 1367
JO - Genomics
JF - Genomics
IS - 4
ER -