D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report

Melissa M. Norberg, Christina M. Gilliam, Anna Villavicencio, Godfrey D. Pearlson, David F. Tolin

Research output: Contribution to journalArticle

Abstract

Despite being the most effective treatment available, as many as one third of patients who receive exposure and response prevention (ERP) for obsessive-compulsive disorder (OCD) do not initially respond to treatment. Recent research suggests that the n-methyl d-aspartate (NMDA) receptor partial agonist D-Cycloserine (DCS) may speed up the course of ERP for OCD rather than enhance it. Thus, it is unclear whether DCS would benefit patients who have proven nonresponsive to ERP and serotonin reuptake inhibitors. The present study evaluated the ability of DCS to enhance ERP for 2 patients with OCD who previously had failed to show adequate response to treatment using time-series analysis. Both patients experienced greater reductions with DCS augmented ERP than they did with prior treatment; however, 1 patient relapsed by the 1-month follow-up. DCS augmented ERP might be an effective method for boosting outcomes in individuals who do not readily respond to ERP.

Original languageEnglish (US)
Pages (from-to)338-345
Number of pages8
JournalCognitive and Behavioral Practice
Volume19
Issue number2
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Cycloserine
Obsessive-Compulsive Disorder
Therapeutics
Aptitude
Serotonin Uptake Inhibitors
Research

Keywords

  • Behavior therapy
  • D-Cycloserine
  • Exposure and response prevention
  • Obsessive-compulsive disorder
  • Treatment nonresponder

ASJC Scopus subject areas

  • Clinical Psychology

Cite this

D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder : A Case Report. / Norberg, Melissa M.; Gilliam, Christina M.; Villavicencio, Anna; Pearlson, Godfrey D.; Tolin, David F.

In: Cognitive and Behavioral Practice, Vol. 19, No. 2, 05.2012, p. 338-345.

Research output: Contribution to journalArticle

Norberg, Melissa M. ; Gilliam, Christina M. ; Villavicencio, Anna ; Pearlson, Godfrey D. ; Tolin, David F. / D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder : A Case Report. In: Cognitive and Behavioral Practice. 2012 ; Vol. 19, No. 2. pp. 338-345.
@article{d7ed4a2c24564c3faaf81f27bceb7c04,
title = "D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report",
abstract = "Despite being the most effective treatment available, as many as one third of patients who receive exposure and response prevention (ERP) for obsessive-compulsive disorder (OCD) do not initially respond to treatment. Recent research suggests that the n-methyl d-aspartate (NMDA) receptor partial agonist D-Cycloserine (DCS) may speed up the course of ERP for OCD rather than enhance it. Thus, it is unclear whether DCS would benefit patients who have proven nonresponsive to ERP and serotonin reuptake inhibitors. The present study evaluated the ability of DCS to enhance ERP for 2 patients with OCD who previously had failed to show adequate response to treatment using time-series analysis. Both patients experienced greater reductions with DCS augmented ERP than they did with prior treatment; however, 1 patient relapsed by the 1-month follow-up. DCS augmented ERP might be an effective method for boosting outcomes in individuals who do not readily respond to ERP.",
keywords = "Behavior therapy, D-Cycloserine, Exposure and response prevention, Obsessive-compulsive disorder, Treatment nonresponder",
author = "Norberg, {Melissa M.} and Gilliam, {Christina M.} and Anna Villavicencio and Pearlson, {Godfrey D.} and Tolin, {David F.}",
year = "2012",
month = "5",
doi = "10.1016/j.cbpra.2011.05.002",
language = "English (US)",
volume = "19",
pages = "338--345",
journal = "Cognitive and Behavioral Practice",
issn = "1077-7229",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder

T2 - A Case Report

AU - Norberg, Melissa M.

AU - Gilliam, Christina M.

AU - Villavicencio, Anna

AU - Pearlson, Godfrey D.

AU - Tolin, David F.

PY - 2012/5

Y1 - 2012/5

N2 - Despite being the most effective treatment available, as many as one third of patients who receive exposure and response prevention (ERP) for obsessive-compulsive disorder (OCD) do not initially respond to treatment. Recent research suggests that the n-methyl d-aspartate (NMDA) receptor partial agonist D-Cycloserine (DCS) may speed up the course of ERP for OCD rather than enhance it. Thus, it is unclear whether DCS would benefit patients who have proven nonresponsive to ERP and serotonin reuptake inhibitors. The present study evaluated the ability of DCS to enhance ERP for 2 patients with OCD who previously had failed to show adequate response to treatment using time-series analysis. Both patients experienced greater reductions with DCS augmented ERP than they did with prior treatment; however, 1 patient relapsed by the 1-month follow-up. DCS augmented ERP might be an effective method for boosting outcomes in individuals who do not readily respond to ERP.

AB - Despite being the most effective treatment available, as many as one third of patients who receive exposure and response prevention (ERP) for obsessive-compulsive disorder (OCD) do not initially respond to treatment. Recent research suggests that the n-methyl d-aspartate (NMDA) receptor partial agonist D-Cycloserine (DCS) may speed up the course of ERP for OCD rather than enhance it. Thus, it is unclear whether DCS would benefit patients who have proven nonresponsive to ERP and serotonin reuptake inhibitors. The present study evaluated the ability of DCS to enhance ERP for 2 patients with OCD who previously had failed to show adequate response to treatment using time-series analysis. Both patients experienced greater reductions with DCS augmented ERP than they did with prior treatment; however, 1 patient relapsed by the 1-month follow-up. DCS augmented ERP might be an effective method for boosting outcomes in individuals who do not readily respond to ERP.

KW - Behavior therapy

KW - D-Cycloserine

KW - Exposure and response prevention

KW - Obsessive-compulsive disorder

KW - Treatment nonresponder

UR - http://www.scopus.com/inward/record.url?scp=84858446664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858446664&partnerID=8YFLogxK

U2 - 10.1016/j.cbpra.2011.05.002

DO - 10.1016/j.cbpra.2011.05.002

M3 - Article

AN - SCOPUS:84858446664

VL - 19

SP - 338

EP - 345

JO - Cognitive and Behavioral Practice

JF - Cognitive and Behavioral Practice

SN - 1077-7229

IS - 2

ER -