Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer

Joseph A. Blansfield; Kimberly E. Beck; Khoi Tran; James C. Yang; Marybeth S. Hughes; Udai S. Kammula; Richard E. Royal; Suzanne L. Topalian; Leah R. Haworth; Catherine Levy; Steven A. Rosenberg; Richard M. Sherry

doi:10.1097/01.cji.0000178913.41256.06

Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer

Joseph A. Blansfield, Kimberly E. Beck, Khoi Tran, James C. Yang, Marybeth S. Hughes, Udai S. Kammula, Richard E. Royal, Suzanne L. Topalian, Leah R. Haworth, Catherine Levy, Steven A. Rosenberg, Richard M. Sherry

School of Medicine

Research output: Contribution to journal › Article

Abstract

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4⁺CD25 ⁺ T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients. This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial report, 7 additional patients with anti-CTLA-4 antibody-induced autoimmune hypophysitis have been accumulated. The characteristics, clinical course, laboratory values, radiographic findings, and treatment of these 8 patients are the focus of this report.

Original language	English (US)
Pages (from-to)	593-598
Number of pages	6
Journal	Journal of Immunotherapy
Volume	28
Issue number	6
DOIs	https://doi.org/10.1097/01.cji.0000178913.41256.06
State	Published - 2005

Keywords

Anti-CTLA-4 antibody
Autoimmune hypophysitis
Autoimmunity
Immunotherapy
Melanoma
Renal cell cancer

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology
Cancer Research

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Blansfield, J. A., Beck, K. E., Tran, K., Yang, J. C., Hughes, M. S., Kammula, U. S., Royal, R. E., Topalian, S. L., Haworth, L. R., Levy, C., Rosenberg, S. A., & Sherry, R. M. (2005). Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. Journal of Immunotherapy, 28(6), 593-598. https://doi.org/10.1097/01.cji.0000178913.41256.06

Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. / Blansfield, Joseph A.; Beck, Kimberly E.; Tran, Khoi; Yang, James C.; Hughes, Marybeth S.; Kammula, Udai S.; Royal, Richard E.; Topalian, Suzanne L.; Haworth, Leah R.; Levy, Catherine; Rosenberg, Steven A.; Sherry, Richard M.

In: Journal of Immunotherapy, Vol. 28, No. 6, 2005, p. 593-598.

Research output: Contribution to journal › Article

Blansfield, JA, Beck, KE, Tran, K, Yang, JC, Hughes, MS, Kammula, US, Royal, RE, Topalian, SL, Haworth, LR, Levy, C, Rosenberg, SA & Sherry, RM 2005, 'Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer', Journal of Immunotherapy, vol. 28, no. 6, pp. 593-598. https://doi.org/10.1097/01.cji.0000178913.41256.06

Blansfield, Joseph A. ; Beck, Kimberly E. ; Tran, Khoi ; Yang, James C. ; Hughes, Marybeth S. ; Kammula, Udai S. ; Royal, Richard E. ; Topalian, Suzanne L. ; Haworth, Leah R. ; Levy, Catherine ; Rosenberg, Steven A. ; Sherry, Richard M. / Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. In: Journal of Immunotherapy. 2005 ; Vol. 28, No. 6. pp. 593-598.

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