Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer

Joseph A. Blansfield, Kimberly E. Beck, Khoi Tran, James C. Yang, Marybeth S. Hughes, Udai S. Kammula, Richard E. Royal, Suzanne L. Topalian, Leah R. Haworth, Catherine Levy, Steven A. Rosenberg, Richard M. Sherry

Research output: Contribution to journalArticle

Abstract

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4+CD25 + T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients. This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial report, 7 additional patients with anti-CTLA-4 antibody-induced autoimmune hypophysitis have been accumulated. The characteristics, clinical course, laboratory values, radiographic findings, and treatment of these 8 patients are the focus of this report.

Original languageEnglish (US)
Pages (from-to)593-598
Number of pages6
JournalJournal of Immunotherapy
Volume28
Issue number6
DOIs
StatePublished - 2005

Keywords

  • Anti-CTLA-4 antibody
  • Autoimmune hypophysitis
  • Autoimmunity
  • Immunotherapy
  • Melanoma
  • Renal cell cancer

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

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  • Cite this

    Blansfield, J. A., Beck, K. E., Tran, K., Yang, J. C., Hughes, M. S., Kammula, U. S., Royal, R. E., Topalian, S. L., Haworth, L. R., Levy, C., Rosenberg, S. A., & Sherry, R. M. (2005). Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. Journal of Immunotherapy, 28(6), 593-598. https://doi.org/10.1097/01.cji.0000178913.41256.06