TY - JOUR
T1 - Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
AU - Blansfield, Joseph A.
AU - Beck, Kimberly E.
AU - Tran, Khoi
AU - Yang, James C.
AU - Hughes, Marybeth S.
AU - Kammula, Udai S.
AU - Royal, Richard E.
AU - Topalian, Suzanne L.
AU - Haworth, Leah R.
AU - Levy, Catherine
AU - Rosenberg, Steven A.
AU - Sherry, Richard M.
PY - 2005
Y1 - 2005
N2 - Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4+CD25 + T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients. This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial report, 7 additional patients with anti-CTLA-4 antibody-induced autoimmune hypophysitis have been accumulated. The characteristics, clinical course, laboratory values, radiographic findings, and treatment of these 8 patients are the focus of this report.
AB - Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4+CD25 + T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients. This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial report, 7 additional patients with anti-CTLA-4 antibody-induced autoimmune hypophysitis have been accumulated. The characteristics, clinical course, laboratory values, radiographic findings, and treatment of these 8 patients are the focus of this report.
KW - Anti-CTLA-4 antibody
KW - Autoimmune hypophysitis
KW - Autoimmunity
KW - Immunotherapy
KW - Melanoma
KW - Renal cell cancer
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U2 - 10.1097/01.cji.0000178913.41256.06
DO - 10.1097/01.cji.0000178913.41256.06
M3 - Article
C2 - 16224277
AN - SCOPUS:27444440093
VL - 28
SP - 593
EP - 598
JO - Journal of Biological Response Modifiers
JF - Journal of Biological Response Modifiers
SN - 1524-9557
IS - 6
ER -