Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

Huizhen Liu, Kent Gunnertoft Jensen, Linh My Tran, Ming Chen, Lin Zhai, Carl Erik Olsen, Helmer Søhoel, Samuel R. Denmeade, John T. Isaacs, S. Brøgger Christensen

Research output: Contribution to journalArticlepeer-review

Abstract

Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.

Original languageEnglish (US)
Pages (from-to)2651-2658
Number of pages8
JournalPhytochemistry
Volume67
Issue number24
DOIs
StatePublished - Dec 2006

Keywords

  • 2,3-Dihydroxy-2-methylbutanoic acid
  • Apiaceae
  • Cytotoxicity
  • Phenylpropanoids
  • Relative configuration
  • Thapsia garganica
  • Thapsigargin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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