Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

Huizhen Liu; Kent Gunnertoft Jensen; Linh My Tran; Ming Chen; Lin Zhai; Carl Erik Olsen; Helmer Søhoel; Samuel R. Denmeade; John T. Isaacs; S. Brøgger Christensen

doi:10.1016/j.phytochem.2006.10.005

Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

Huizhen Liu, Kent Gunnertoft Jensen, Linh My Tran, Ming Chen, Lin Zhai, Carl Erik Olsen, Helmer Søhoel, Samuel R. Denmeade, John T. Isaacs, S. Brøgger Christensen

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.

Original language	English (US)
Pages (from-to)	2651-2658
Number of pages	8
Journal	Phytochemistry
Volume	67
Issue number	24
DOIs	https://doi.org/10.1016/j.phytochem.2006.10.005
State	Published - Dec 2006

Keywords

2,3-Dihydroxy-2-methylbutanoic acid
Apiaceae
Cytotoxicity
Phenylpropanoids
Relative configuration
Thapsia garganica
Thapsigargin

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

Access to Document

10.1016/j.phytochem.2006.10.005

Cite this

@article{033edd8ce00a43ac8ffc186483da666f,

title = "Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica",

abstract = "Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.",

keywords = "2,3-Dihydroxy-2-methylbutanoic acid, Apiaceae, Cytotoxicity, Phenylpropanoids, Relative configuration, Thapsia garganica, Thapsigargin",

author = "Huizhen Liu and Jensen, {Kent Gunnertoft} and Tran, {Linh My} and Ming Chen and Lin Zhai and Olsen, {Carl Erik} and Helmer S{\o}hoel and Denmeade, {Samuel R.} and Isaacs, {John T.} and {Br{\o}gger Christensen}, S.",

note = "Funding Information: This work was supported by the Danish Cancer Society, Carlsbergfondet and Apotekerfonden af 1991.",

year = "2006",

month = dec,

doi = "10.1016/j.phytochem.2006.10.005",

language = "English (US)",

volume = "67",

pages = "2651--2658",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

number = "24",

}

TY - JOUR

T1 - Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

AU - Liu, Huizhen

AU - Jensen, Kent Gunnertoft

AU - Tran, Linh My

AU - Chen, Ming

AU - Zhai, Lin

AU - Olsen, Carl Erik

AU - Søhoel, Helmer

AU - Denmeade, Samuel R.

AU - Isaacs, John T.

AU - Brøgger Christensen, S.

N1 - Funding Information: This work was supported by the Danish Cancer Society, Carlsbergfondet and Apotekerfonden af 1991.

PY - 2006/12

Y1 - 2006/12

N2 - Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.

AB - Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.

KW - 2,3-Dihydroxy-2-methylbutanoic acid

KW - Apiaceae

KW - Cytotoxicity

KW - Phenylpropanoids

KW - Relative configuration

KW - Thapsia garganica

KW - Thapsigargin

UR - http://www.scopus.com/inward/record.url?scp=33751182105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751182105&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2006.10.005

DO - 10.1016/j.phytochem.2006.10.005

M3 - Article

C2 - 17098264

AN - SCOPUS:33751182105

SN - 0031-9422

VL - 67

SP - 2651

EP - 2658

JO - Phytochemistry

JF - Phytochemistry

IS - 24

ER -

Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this