Cytotoxic antibody in normal human serums reactive with tumor cells from acute lymphocytic leukemia

Wilma B. Bias, George W. Santos, Philip J. Burke, Gordon M. Mullins, Richard L. Humphrey

Research output: Contribution to journalArticle

Abstract

Serums showing complement-dependent cytotoxic reactions to acute lymphocytic leukemia cells were detected in three normal unimmunized subjects. These serums were reactive with tumor cells from 514 (514 tested) acute lymphocytic leukemia patients, and three (12 tested) patients with acute myelocytic leukemia; they did not react with tumor cells from patients with acute monocytic leukemia (two tested), with chronic lymphocytic leukemia (two tested) or with leukolymphosarcoma (two tested); nor did they react with normal lymphocytes from 52 different donors. These reactive serums appear to recognize antigens primarily associated with acute lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)304-306
Number of pages3
JournalScience
Volume178
Issue number4058
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • General

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    Bias, W. B., Santos, G. W., Burke, P. J., Mullins, G. M., & Humphrey, R. L. (1972). Cytotoxic antibody in normal human serums reactive with tumor cells from acute lymphocytic leukemia. Science, 178(4058), 304-306. https://doi.org/10.1126/science.178.4058.304