Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae)

José C. Aponte, Han Yang, Abraham J. Vaisberg, Denis Castillo, Edith Málaga, Manuela Verástegui, Lavona K. Casson, Nicole Stivers, Paula J. Bates, Rosario Rojas, Irma Fernandez, Walter H. Lewis, César Sarasara, Michel Sauvain, Robert H. Gilman, Gerald B. Hammond

Research output: Contribution to journalArticlepeer-review

Abstract

A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ent-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (1), I (2), and R (3), as well as of two pseudoguaianolids, damsin (4) and confertin (5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.

Original languageEnglish (US)
Pages (from-to)705-707
Number of pages3
JournalPlanta Medica
Volume76
Issue number7
DOIs
StatePublished - 2010

Keywords

  • Ambrosia peruviana
  • Antileishmania
  • Asteraceae
  • Cytotoxic
  • Plagiochila disticha
  • Plagiochilaceae
  • Trypanoside
  • Tuberculosis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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