Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum

José C. Aponte, Zhuang Jin, Abraham J. Vaisberg, Denis Castillo, Edith Málaga, Walter H. Lewis, Michel Sauvain, Robert H. Gilman, Gerald B. Hammond

Research output: Contribution to journalArticlepeer-review

Abstract

An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6- methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.

Original languageEnglish (US)
Pages (from-to)1597-1599
Number of pages3
JournalPlanta Medica
Volume77
Issue number14
DOIs
StatePublished - 2011

Keywords

  • Compositae
  • Cremastosperma microcarpum Annonaceae
  • Mikania decora
  • anticancer
  • antileishmania
  • trypanoside

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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