Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4- T cells

Elitsa Antonova Ananieva; Chirag H. Patel; Charles H. Drake; Jonathan D. Powell; Susan M. Hutson

doi:10.1074/jbc.M114.554113

Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4- T cells

Elitsa Antonova Ananieva, Chirag H. Patel, Charles H. Drake, Jonathan D. Powell, Susan M. Hutson

School of Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Background: Cytosolic branched chain aminotransferase (BCATc) initiates Leu catabolism. In T cells, Leu activates mTORC1, the role of BCATc is unknown. Results: BCATc stimulates Leu transamination, whereas loss of BCATc expression increases Leu concentrations, mTORC1 signaling, and glycolysis in T cells. Conclusion: BCATc is a novel immunosuppressive enzyme controlling Leu supply for mTORC1 in T cells. Significance: A new link is revealed between amino acid metabolism and the immune response.

Original language	English (US)
Pages (from-to)	18793-18804
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M114.554113
State	Published - Jul 4 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4- T cells",

abstract = "Background: Cytosolic branched chain aminotransferase (BCATc) initiates Leu catabolism. In T cells, Leu activates mTORC1, the role of BCATc is unknown. Results: BCATc stimulates Leu transamination, whereas loss of BCATc expression increases Leu concentrations, mTORC1 signaling, and glycolysis in T cells. Conclusion: BCATc is a novel immunosuppressive enzyme controlling Leu supply for mTORC1 in T cells. Significance: A new link is revealed between amino acid metabolism and the immune response.",

author = "Ananieva, {Elitsa Antonova} and Patel, {Chirag H.} and Drake, {Charles H.} and Powell, {Jonathan D.} and Hutson, {Susan M.}",

year = "2014",

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doi = "10.1074/jbc.M114.554113",

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T1 - Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4- T cells

AU - Ananieva, Elitsa Antonova

AU - Patel, Chirag H.

AU - Drake, Charles H.

AU - Powell, Jonathan D.

AU - Hutson, Susan M.

PY - 2014/7/4

Y1 - 2014/7/4

N2 - Background: Cytosolic branched chain aminotransferase (BCATc) initiates Leu catabolism. In T cells, Leu activates mTORC1, the role of BCATc is unknown. Results: BCATc stimulates Leu transamination, whereas loss of BCATc expression increases Leu concentrations, mTORC1 signaling, and glycolysis in T cells. Conclusion: BCATc is a novel immunosuppressive enzyme controlling Leu supply for mTORC1 in T cells. Significance: A new link is revealed between amino acid metabolism and the immune response.

AB - Background: Cytosolic branched chain aminotransferase (BCATc) initiates Leu catabolism. In T cells, Leu activates mTORC1, the role of BCATc is unknown. Results: BCATc stimulates Leu transamination, whereas loss of BCATc expression increases Leu concentrations, mTORC1 signaling, and glycolysis in T cells. Conclusion: BCATc is a novel immunosuppressive enzyme controlling Leu supply for mTORC1 in T cells. Significance: A new link is revealed between amino acid metabolism and the immune response.

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Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4- T cells

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