Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane

Wenhong Xu, Yongge Liu, Sheng Wang, Todd McDonald, Jennifer E. Van Eyk, Agnieszka Sidor, Brian O'Rourke

Research output: Contribution to journalArticle

Abstract

Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate-sensitive K+ channel (mitoKATP) is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoKCa) of guinea pig ventricular cells. MitoKCa significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoKCa protected hearts against infarction.

Original languageEnglish (US)
Pages (from-to)1029-1033
Number of pages5
JournalScience
Volume298
Issue number5595
DOIs
StatePublished - Nov 1 2002

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Calcium-Activated Potassium Channels
Mitochondrial Membranes
Potassium Channels
Ion Channels
Muscle Cells
Infarction
Cell Survival
Guinea Pigs
Ischemia
Adenosine Triphosphate
Membranes
Wounds and Injuries

ASJC Scopus subject areas

  • General

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Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane. / Xu, Wenhong; Liu, Yongge; Wang, Sheng; McDonald, Todd; Van Eyk, Jennifer E.; Sidor, Agnieszka; O'Rourke, Brian.

In: Science, Vol. 298, No. 5595, 01.11.2002, p. 1029-1033.

Research output: Contribution to journalArticle

Xu, W, Liu, Y, Wang, S, McDonald, T, Van Eyk, JE, Sidor, A & O'Rourke, B 2002, 'Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane', Science, vol. 298, no. 5595, pp. 1029-1033. https://doi.org/10.1126/science.1074360
Xu W, Liu Y, Wang S, McDonald T, Van Eyk JE, Sidor A et al. Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane. Science. 2002 Nov 1;298(5595):1029-1033. https://doi.org/10.1126/science.1074360
Xu, Wenhong ; Liu, Yongge ; Wang, Sheng ; McDonald, Todd ; Van Eyk, Jennifer E. ; Sidor, Agnieszka ; O'Rourke, Brian. / Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane. In: Science. 2002 ; Vol. 298, No. 5595. pp. 1029-1033.
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