Cytopathologic characteristics of SMARCB1 (INI-1) deficient sinonasal carcinoma: A potential diagnostic pitfall

Derek B. Allison, Justin A. Bishop, Syed Z Ali

Research output: Contribution to journalArticle

Abstract

Tumors of the head and neck are extremely diverse and a subset are poorly differentiated and difficult to classify. Recently, a new entity has been described with rhabdoid and/or plasmacytoid cytologic features and a characteristic genetic signature—inactivation of the SMARCB1 (INI-1) tumor suppressor gene. To date, only 16 cases of SMARCB1 (INI-1) deficient sinonasal carcinoma have been described, and there are currently no reports of the cytopathologic features by fine needle aspiration (FNA) cytology. A case of a 77-year-old man who presented with a posterior ethmoid sinus lesion with invasion into the skull base and bone was reported. FNA cytology of a right retropharyngeal lymph node revealed relatively monomorphic, loosely cohesive clusters of plasmacytoid cells with occasional nucleoli, rare intranuclear cytoplasmic inclusions, and mitotic figures in a background of necrosis and absence of overt squamous or glandular differentiation. A diagnosis of metastatic myoepithelial carcinoma was made; however, retrospectively, the surgical excision showed loss of the SMARCB1 (INI-1) tumor suppressor gene by immunohistochemistry. In summary, the cytomorphologic features of SMARCB1 (INI-1) deficient sinonasal carcinoma are relatively nonspecific and overlap with other regional tumors, including myoepithelial neoplasms. As a result, this entity should be considered in the differential diagnosis for a plasmacytoid tumor arising in the sinonasal tract by FNA cytology. Diagn.

Original languageEnglish (US)
Pages (from-to)700-703
Number of pages4
JournalDiagnostic Cytopathology
Volume44
Issue number8
DOIs
StatePublished - Aug 1 2016

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Fine Needle Biopsy
Cell Biology
Tumor Suppressor Genes
Carcinoma
Myoepithelioma
Ethmoid Sinus
Intranuclear Inclusion Bodies
Neoplasms
Inclusion Bodies
Skull Base
Differential Diagnosis
Necrosis
Neck
Lymph Nodes
Immunohistochemistry
Head
Bone and Bones

Keywords

  • cytopathology
  • fine needle aspiration
  • sinonasal carcinoma
  • SMARCB1 (INI1)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Cytopathologic characteristics of SMARCB1 (INI-1) deficient sinonasal carcinoma : A potential diagnostic pitfall. / Allison, Derek B.; Bishop, Justin A.; Ali, Syed Z.

In: Diagnostic Cytopathology, Vol. 44, No. 8, 01.08.2016, p. 700-703.

Research output: Contribution to journalArticle

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