TY - JOUR
T1 - Cytomegalovirus retinitis and viral resistance
T2 - Ganciclovir resistance
AU - Jabs, Douglas A.
AU - Enger, Cheryl
AU - Dunn, J. P.
AU - Forman, Michael
N1 - Funding Information:
Received 29 May 1997; revised 7 October 1997. The study was approved by the Johns Hopkins Medical Institutions Joint Committee for Clinical Investigation, and written informed consent was obtained from all enrolled patients. Grant support: NIH (EY-10268). Reprints or correspondence: Dr. Douglas A. Jabs, Wilmer Ophthalmological Institute, 550 N. Broadway, Suite 700, Baltimore, MD 21205 (dajabs@ welchlink.welch.jhu.edu).
PY - 1998
Y1 - 1998
N2 - Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in patients with AIDS and a substantial cause of visual loss. With long-term therapy, resistant CMV may develop. In a prospective study of 108 patients with CMV retinitis, 80.6% of patients were found to have either a positive blood culture or positive urine culture for CMV at the diagnosis of retinitis. At diagnosis of retinitis, 0.9% and 2.7% of patients had a ganciclovir-resistant blood culture isolate and urine culture isolate, respectively. Of 76 patients initially treated with ganciclovir, 11.4% had a resistant blood or urine culture isolate by 6 months of treatment and 27.5% by 9 months. The development of ganciclovir resistance during follow-up correlated with the occurrence of CMV retinitis in the contralateral eye (odds ratio = 9.06, P = .003).
AB - Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in patients with AIDS and a substantial cause of visual loss. With long-term therapy, resistant CMV may develop. In a prospective study of 108 patients with CMV retinitis, 80.6% of patients were found to have either a positive blood culture or positive urine culture for CMV at the diagnosis of retinitis. At diagnosis of retinitis, 0.9% and 2.7% of patients had a ganciclovir-resistant blood culture isolate and urine culture isolate, respectively. Of 76 patients initially treated with ganciclovir, 11.4% had a resistant blood or urine culture isolate by 6 months of treatment and 27.5% by 9 months. The development of ganciclovir resistance during follow-up correlated with the occurrence of CMV retinitis in the contralateral eye (odds ratio = 9.06, P = .003).
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U2 - 10.1086/514249
DO - 10.1086/514249
M3 - Article
C2 - 9498461
AN - SCOPUS:0031932271
SN - 0022-1899
VL - 177
SP - 770
EP - 773
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -