Cytomegalovirus reactivation after matched sibling donor reduced-intensity conditioning allogeneic hematopoietic stem cell transplant correlates with donor killer immunoglobulin-like receptor genotype

Ronald M. Sobecks, Medhat Askar, Dawn Thomas, Lisa Rybicki, Matt Kalaycio, Robert Dean, Robin Avery, Sherif Mossad, Edward Copelan, Brian J. Bolwell

Research output: Contribution to journalArticle

Abstract

Objectives: Cytomegalovirus reactivation is common after reduced-intensity conditioning allogeneic hematopoietic stem cell transplant. Natural killer and T cells mediate immunity against viruses including cytomegalovirus. The alloreactivity of Natural killer cells and some T-cell subsets is mediated through the interaction of their killer immunoglobulin-like receptors with target cell ligands. This study sought to assess whether donor inhibitory or activating killer immunoglobulin-like receptor genotypes may influence post-transplant cytomegalovirus reactivation in transplant recipients. Materials and Methods: We analyzed 64 patients who underwent T-cell replete, matched sibling donor reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation at our institution. Transplant recipients were categorized according to their HLA inhibitory killer immunoglobulin-like receptor ligand groups. Donor killer immunoglobulin-like receptor genotypes were determined and then were assessed for correlations with cytomegalovirus reactivation in transplant recipients. Results: No differences in cytomegalovirus reactivation were observed when comparing those with or without missing inhibitory killer immunoglobulin-like receptor ligands. When considering the number of donor activating killer immunoglobulin-like receptor genes, those with 5 or 6 had less cytomegalovirus reactivation than those with 1 to 4 (19% vs 48%; P =.029). The difference could not be attributed to baseline patient or transplant characteristics. No specific activating killer immunoglobulin-like receptor genotype was found to be associated with cytomegalovirus reactivation. Conclusions: These observations indicate that assessment of donor killer immunoglobulin-like receptor genotype may have important implications for predicting cytomegalovirus reactivation after T-cell replete, matched sibling donor reducedintensity conditioning allogeneic hematopoietic stem cell transplant.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalExperimental and Clinical Transplantation
Volume9
Issue number1
StatePublished - Feb 2011
Externally publishedYes

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Keywords

  • Allogeneic hematopoietic stem cell transplant
  • Cytomegalovirus
  • Killer immunoglobulinlike receptors
  • Matched sibling donor
  • Reduced-intensity conditioning

ASJC Scopus subject areas

  • Transplantation

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