Cytomegalovirus Kinetics Following Primary Infection in Healthy Women

Michael S. Forman, Dhananjay Vaidya, Oluwaseyi Bolorunduro, Marie Diener-West, Robert F. Pass, Ravit Arav-Boger

Research output: Contribution to journalArticlepeer-review

Abstract

The kinetics of cytomegalovirus (CMV) DNA in infected asymptomatic hosts are largely unknown. We measured viral load (VL) in 124 fluid samples (oral, urine, vaginal, blood) collected from 21 women who acquired CMV. A quantitative real-time polymerase chain reaction assay of US17, which correlated with clinical assays, was used. VL decreased following primary infection in all fluids. The geometric mean VL of vaginal fluid was significantly higher than that of other sources: oral (3.89; 95% confidence interval [CI], 1.43-10.57), urine (6.36; 95% CI, 2.48-16.32), and whole blood (11.88; 95% CI, 4.12-34.20). Vaginal CMV shedding may provide a route for sexual and possibly perinatal transmission.

Original languageEnglish (US)
Pages (from-to)1523-1526
Number of pages4
JournalJournal of Infectious Diseases
Volume215
Issue number10
DOIs
StatePublished - May 15 2017

Keywords

  • Cytomegalovirus
  • US17 real-time PCR
  • normal host
  • viral loads

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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