Cytomegalovirus infections in bone marrow transplant recipients given intensive cytoreductive therapy

J. R. Wingard, S. Piantadosi, W. H. Burns, M. L. Zahurak, G. W. Santos, R. Saral

    Research output: Contribution to journalArticle

    Abstract

    Cytomegalovirus (CMV) infections were studied in 785 bone marrow transplant recipients given intensive cytoreductive therapy. CMV excretion occurred in 24%, viremia in 9%, seroconversion in 40%, and overall active infection in 47%. CMV disease was much less common. Retinitis, enteritis, and pneumonitis occurred in only one, five (10 years, and acute graft-vs.-host disease, while the use of cyclosporine as prophylaxis against graft-vs.-host disease was protective. Although active infection rates did not decrease, the rates of CMV pneumonitis in allograft recipients during successive years declined significantly (P <.001).

    Original languageEnglish (US)
    JournalReviews of Infectious Diseases
    Volume12
    Issue numberSUPPL. 7
    StatePublished - 1990

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    Cytomegalovirus Infections
    Cytomegalovirus
    Bone Marrow
    Pneumonia
    Transplants
    Retinitis
    Enteritis
    Viremia
    Infection
    Cyclosporine
    Allografts
    Therapeutics
    Transplant Recipients

    ASJC Scopus subject areas

    • Microbiology (medical)

    Cite this

    Wingard, J. R., Piantadosi, S., Burns, W. H., Zahurak, M. L., Santos, G. W., & Saral, R. (1990). Cytomegalovirus infections in bone marrow transplant recipients given intensive cytoreductive therapy. Reviews of Infectious Diseases, 12(SUPPL. 7).

    Cytomegalovirus infections in bone marrow transplant recipients given intensive cytoreductive therapy. / Wingard, J. R.; Piantadosi, S.; Burns, W. H.; Zahurak, M. L.; Santos, G. W.; Saral, R.

    In: Reviews of Infectious Diseases, Vol. 12, No. SUPPL. 7, 1990.

    Research output: Contribution to journalArticle

    Wingard, JR, Piantadosi, S, Burns, WH, Zahurak, ML, Santos, GW & Saral, R 1990, 'Cytomegalovirus infections in bone marrow transplant recipients given intensive cytoreductive therapy', Reviews of Infectious Diseases, vol. 12, no. SUPPL. 7.
    Wingard JR, Piantadosi S, Burns WH, Zahurak ML, Santos GW, Saral R. Cytomegalovirus infections in bone marrow transplant recipients given intensive cytoreductive therapy. Reviews of Infectious Diseases. 1990;12(SUPPL. 7).
    Wingard, J. R. ; Piantadosi, S. ; Burns, W. H. ; Zahurak, M. L. ; Santos, G. W. ; Saral, R. / Cytomegalovirus infections in bone marrow transplant recipients given intensive cytoreductive therapy. In: Reviews of Infectious Diseases. 1990 ; Vol. 12, No. SUPPL. 7.
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    AU - Santos, G. W.

    AU - Saral, R.

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    AB - Cytomegalovirus (CMV) infections were studied in 785 bone marrow transplant recipients given intensive cytoreductive therapy. CMV excretion occurred in 24%, viremia in 9%, seroconversion in 40%, and overall active infection in 47%. CMV disease was much less common. Retinitis, enteritis, and pneumonitis occurred in only one, five (10 years, and acute graft-vs.-host disease, while the use of cyclosporine as prophylaxis against graft-vs.-host disease was protective. Although active infection rates did not decrease, the rates of CMV pneumonitis in allograft recipients during successive years declined significantly (P <.001).

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