Cytomegalovirus infections in bone marrow transplant recipients given intensive Cytoreductive therapy

John R. Wingard, Steven Piantadosi, William H. Bums, Marianna L. Zahurak, George W. Santos, Rein Saral

Research output: Contribution to journalArticlepeer-review

Abstract

Cytomegalovirus (CMV) infections were studied in 785 bone marrow transplant recipients given intensive cytoreductive therapy. CMV excretion occurred in 24%, viremia in 9%, seroconversion in 40%, and overall active infection in 47%. CMV disease was much less common. Retinitis, enteritis, and pneumonitis occurred in only one, five (<1%), and 55 (7%) of the patients, respectively. Allograft recipients were more likely to develop CMV disease than were autograft patients (P =.0001) despite comparable rates of active CMV infection. CMV disease was rare after primary infection in both autograft and allograft recipients (0 and 10%, respectively). In contrast, CMV disease occurred in 16% of seropositive allograft recipients. Among allograft recipients, risk factors for CMV pneumonitis were seropositivity, age >10 years, and acute graft-vs.-host disease, while the use of cyclosporine as prophylaxis against graft-vs.-host disease was protective. Although active infection rates did not decrease, the rates of CMV pneumonitis in allograft recipients during successive years declined significantly (P <.001).

Original languageEnglish (US)
Pages (from-to)S793-S804
JournalReviews of infectious diseases
Volume12
DOIs
StatePublished - Sep 1990
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

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