Cytomegalovirus infections after treatment with daclizumab, an anti IL-2 receptor antibody, for prevention of renal allograft rejection

Paul Hengster; Mark D. Pescovitz; Debra Hyatt; Raimund Margreiter; Lars Bäckman; Francois Berthoux; Andrew Bradley; Ginny Bumgardner; James Burdick; Vincenzo Cambi; Gary Chan; Bernard Charpentier; Pierre Daloze; Henrik Ekberg; Göran Gannedahl; Robert Gaston; Phillip Halloran; Ian Hardie; Ingeborg Hauser; Robert Johnson; Paul Keown; Michèle Kessler; Bryce Kiberd; Robert Kirkman; Andrew Lazarovits; Arthur J. Matas; Ferdinand Mühlbacher; Bjorn Nashan; John Neylan; Nils Persson; Mark Pescovitz; Guiseppe Piccoli; Rudolf Pichlmayr; Claudio Ponticelli; Stuart Rodgers; Michael E. Shapiro; David Tiller; Gunnar Tufveson; Gunnar Tyden; Yves Vanrentergehm; Antonio Vercellone; Paul Vialtel; Flavio Vincenti; Samuel Weinstein; Alan Wilkinson

doi:10.1097/00007890-199907270-00028

Cytomegalovirus infections after treatment with daclizumab, an anti IL-2 receptor antibody, for prevention of renal allograft rejection

Paul Hengster, Mark D. Pescovitz, Debra Hyatt, Raimund Margreiter, Lars Bäckman, Francois Berthoux, Andrew Bradley, Ginny Bumgardner, James Burdick, Vincenzo Cambi, Gary Chan, Bernard Charpentier, Pierre Daloze, Henrik Ekberg, Göran Gannedahl, Robert Gaston, Phillip Halloran, Ian Hardie, Ingeborg Hauser, Robert JohnsonPaul Keown, Michèle Kessler, Bryce Kiberd, Robert Kirkman, Andrew Lazarovits, Arthur J. Matas, Ferdinand Mühlbacher, Bjorn Nashan, John Neylan, Nils Persson, Mark Pescovitz, Guiseppe Piccoli, Rudolf Pichlmayr, Claudio Ponticelli, Stuart Rodgers, Michael E. Shapiro, David Tiller, Gunnar Tufveson, Gunnar Tyden, Yves Vanrentergehm, Antonio Vercellone, Paul Vialtel, Flavio Vincenti, Samuel Weinstein, Alan Wilkinson

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Abstract

Daclizumab is a newly developed humanized anti-IL-2 receptor monoclonal antibody. We describe the effect of adding daclizumab to conventional dual or triple cyclosporine A immunosuppressive therapy on the incidence and nature of cytomegalovirus (CMV) infections in patients receiving a first cadaveric renal graft. In the triple therapy study there was no evidence of any difference in CMV rate or course of disease between the two treatment arms, although in the dual therapy study a decrease in the incidence of CMV infection was observed in the patients treated with daclizumab. The onset of CMV disease was markedly delayed in the daclizumab groups in both studies. Daclizumab can effectively reduce the risk of acute rejection without causing a concomitant increase in opportunistic infections, and by decreasing the need for antirejection therapy may also have a beneficial effect on CMV infection rates.

Original language	English (US)
Pages (from-to)	310-313
Number of pages	4
Journal	Transplantation
Volume	68
Issue number	2
DOIs	https://doi.org/10.1097/00007890-199907270-00028
State	Published - Jul 27 1999
Externally published	Yes

ASJC Scopus subject areas

Transplantation

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10.1097/00007890-199907270-00028

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Hengster, P., Pescovitz, M. D., Hyatt, D., Margreiter, R., Bäckman, L., Berthoux, F., Bradley, A., Bumgardner, G., Burdick, J., Cambi, V., Chan, G., Charpentier, B., Daloze, P., Ekberg, H., Gannedahl, G., Gaston, R., Halloran, P., Hardie, I., Hauser, I., ... Wilkinson, A. (1999). Cytomegalovirus infections after treatment with daclizumab, an anti IL-2 receptor antibody, for prevention of renal allograft rejection. Transplantation, 68(2), 310-313. https://doi.org/10.1097/00007890-199907270-00028

Hengster, P, Pescovitz, MD, Hyatt, D, Margreiter, R, Bäckman, L, Berthoux, F, Bradley, A, Bumgardner, G, Burdick, J, Cambi, V, Chan, G, Charpentier, B, Daloze, P, Ekberg, H, Gannedahl, G, Gaston, R, Halloran, P, Hardie, I, Hauser, I, Johnson, R, Keown, P, Kessler, M, Kiberd, B, Kirkman, R, Lazarovits, A, Matas, AJ, Mühlbacher, F, Nashan, B, Neylan, J, Persson, N, Pescovitz, M, Piccoli, G, Pichlmayr, R, Ponticelli, C, Rodgers, S, Shapiro, ME, Tiller, D, Tufveson, G, Tyden, G, Vanrentergehm, Y, Vercellone, A, Vialtel, P, Vincenti, F, Weinstein, S & Wilkinson, A 1999, 'Cytomegalovirus infections after treatment with daclizumab, an anti IL-2 receptor antibody, for prevention of renal allograft rejection', Transplantation, vol. 68, no. 2, pp. 310-313. https://doi.org/10.1097/00007890-199907270-00028

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abstract = "Daclizumab is a newly developed humanized anti-IL-2 receptor monoclonal antibody. We describe the effect of adding daclizumab to conventional dual or triple cyclosporine A immunosuppressive therapy on the incidence and nature of cytomegalovirus (CMV) infections in patients receiving a first cadaveric renal graft. In the triple therapy study there was no evidence of any difference in CMV rate or course of disease between the two treatment arms, although in the dual therapy study a decrease in the incidence of CMV infection was observed in the patients treated with daclizumab. The onset of CMV disease was markedly delayed in the daclizumab groups in both studies. Daclizumab can effectively reduce the risk of acute rejection without causing a concomitant increase in opportunistic infections, and by decreasing the need for antirejection therapy may also have a beneficial effect on CMV infection rates.",

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AU - Hengster, Paul

AU - Pescovitz, Mark D.

AU - Hyatt, Debra

AU - Margreiter, Raimund

AU - Bäckman, Lars

AU - Berthoux, Francois

AU - Bradley, Andrew

AU - Bumgardner, Ginny

AU - Burdick, James

AU - Cambi, Vincenzo

AU - Chan, Gary

AU - Charpentier, Bernard

AU - Daloze, Pierre

AU - Ekberg, Henrik

AU - Gannedahl, Göran

AU - Gaston, Robert

AU - Halloran, Phillip

AU - Hardie, Ian

AU - Hauser, Ingeborg

AU - Johnson, Robert

AU - Keown, Paul

AU - Kessler, Michèle

AU - Kiberd, Bryce

AU - Kirkman, Robert

AU - Lazarovits, Andrew

AU - Matas, Arthur J.

AU - Mühlbacher, Ferdinand

AU - Nashan, Bjorn

AU - Neylan, John

AU - Persson, Nils

AU - Pescovitz, Mark

AU - Piccoli, Guiseppe

AU - Pichlmayr, Rudolf

AU - Ponticelli, Claudio

AU - Rodgers, Stuart

AU - Shapiro, Michael E.

AU - Tiller, David

AU - Tufveson, Gunnar

AU - Tyden, Gunnar

AU - Vanrentergehm, Yves

AU - Vercellone, Antonio

AU - Vialtel, Paul

AU - Vincenti, Flavio

AU - Weinstein, Samuel

AU - Wilkinson, Alan

PY - 1999/7/27

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N2 - Daclizumab is a newly developed humanized anti-IL-2 receptor monoclonal antibody. We describe the effect of adding daclizumab to conventional dual or triple cyclosporine A immunosuppressive therapy on the incidence and nature of cytomegalovirus (CMV) infections in patients receiving a first cadaveric renal graft. In the triple therapy study there was no evidence of any difference in CMV rate or course of disease between the two treatment arms, although in the dual therapy study a decrease in the incidence of CMV infection was observed in the patients treated with daclizumab. The onset of CMV disease was markedly delayed in the daclizumab groups in both studies. Daclizumab can effectively reduce the risk of acute rejection without causing a concomitant increase in opportunistic infections, and by decreasing the need for antirejection therapy may also have a beneficial effect on CMV infection rates.

AB - Daclizumab is a newly developed humanized anti-IL-2 receptor monoclonal antibody. We describe the effect of adding daclizumab to conventional dual or triple cyclosporine A immunosuppressive therapy on the incidence and nature of cytomegalovirus (CMV) infections in patients receiving a first cadaveric renal graft. In the triple therapy study there was no evidence of any difference in CMV rate or course of disease between the two treatment arms, although in the dual therapy study a decrease in the incidence of CMV infection was observed in the patients treated with daclizumab. The onset of CMV disease was markedly delayed in the daclizumab groups in both studies. Daclizumab can effectively reduce the risk of acute rejection without causing a concomitant increase in opportunistic infections, and by decreasing the need for antirejection therapy may also have a beneficial effect on CMV infection rates.

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ER -

Cytomegalovirus infections after treatment with daclizumab, an anti IL-2 receptor antibody, for prevention of renal allograft rejection

Abstract

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