Cytomegalovirus infection and the risk of mortality and frailty in older women: A prospective observational cohort study

George C. Wang, Wen Hong L. Kao, Peter Murakami, Qian Li Xue, Roger B. Chiou, Barbara Detrick, John F. McDyer, Richard D. Semba, Vincenzo Casolaro, Jeremy D. Walston, Linda P. Fried

Research output: Contribution to journalArticlepeer-review

Abstract

Cytomegalovirus (CMV), a prevalent pathogen, causes severe disease in immunocompromised humans. However, present understanding is limited regarding the long-term clinical effect of persistent CMV infection in immunocompetent adults. The authors conducted a prospective observational cohort study (1992-2002) of 635 community-dwelling women in Baltimore, Maryland, aged 70-79 years in the Women's Health and Aging Studies to examine the effect of CMV infection on the risk of frailty, a common geriatric syndrome, and mortality in older women. The effect of baseline serum CMV antibody (immunoglobulin G) concentration on the risk of 3-year incident frailty, defined by using a 5-component measure, and 5-year mortality was examined with Cox proportional hazards models. Compared with those who were CMV seronegative, women in the highest quartile of CMV antibody concentration had a greater incidence of frailty (hazard ratio = 3.46, 95% confidence interval: 1.45, 8.27) and mortality (hazard ratio = 3.81, 95% confidence interval: 1.64, 8.83). After adjustment for potential confounders, CMV antibody concentration in the highest quartile independently increased the risk of 5-year mortality (hazard ratio = 2.79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection.

Original languageEnglish (US)
Pages (from-to)1144-1152
Number of pages9
JournalAmerican journal of epidemiology
Volume171
Issue number10
DOIs
StatePublished - May 2010

Keywords

  • Antibodies
  • Cytomegalovirus
  • Frail elderly
  • Immunoglobulin G
  • Inflammation
  • Interleukin-6
  • Mortality
  • Viral
  • Virus latency

ASJC Scopus subject areas

  • Epidemiology

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