Cytomegalovirus infection and the risk of mortality and frailty in older women: A prospective observational cohort study

George C. Wang, Wen-Hong Linda Kao, Peter Murakami, Qian Li Xue, Roger B. Chiou, Barbara Detrick, John F. McDyer, Richard D. Semba, Vincenzo Casolaro, Jeremy D. Walston, Linda P. Fried

Research output: Contribution to journalArticlepeer-review

Abstract

Cytomegalovirus (CMV), a prevalent pathogen, causes severe disease in immunocompromised humans. However, present understanding is limited regarding the long-term clinical effect of persistent CMV infection in immunocompetent adults. The authors conducted a prospective observational cohort study (1992-2002) of 635 community-dwelling women in Baltimore, Maryland, aged 70-79 years in the Women's Health and Aging Studies to examine the effect of CMV infection on the risk of frailty, a common geriatric syndrome, and mortality in older women. The effect of baseline serum CMV antibody (immunoglobulin G) concentration on the risk of 3-year incident frailty, defined by using a 5-component measure, and 5-year mortality was examined with Cox proportional hazards models. Compared with those who were CMV seronegative, women in the highest quartile of CMV antibody concentration had a greater incidence of frailty (hazard ratio = 3.46, 95% confidence interval: 1.45, 8.27) and mortality (hazard ratio = 3.81, 95% confidence interval: 1.64, 8.83). After adjustment for potential confounders, CMV antibody concentration in the highest quartile independently increased the risk of 5-year mortality (hazard ratio = 2.79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection.

Original languageEnglish (US)
Pages (from-to)1144-1152
Number of pages9
JournalAmerican journal of epidemiology
Volume171
Issue number10
DOIs
StatePublished - May 2010

Keywords

  • Antibodies
  • Cytomegalovirus
  • Frail elderly
  • Immunoglobulin G
  • Inflammation
  • Interleukin-6
  • Mortality
  • Viral
  • Virus latency

ASJC Scopus subject areas

  • Epidemiology

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