Cytomegalovirus infection and non-neutropenic fever after autologous stem cell transplantation: High rates of reactivation in patients with multiple myeloma and lymphoma

Athanasios Fassas, J. Bolaños-Meade, L. N. Buddharaju, A. Rapoport, M. Cottler-Fox, T. Chen, J. C. Lovchik, A. Cross, G. Tricot

Research output: Contribution to journalArticle

Abstract

In a retrospective study, we examined the association between cytomegalovirus (CMV) infection and non-neutropenic fever immediately following autologous peripheral blood stem cell transplantation for a variety of haematological malignancies and solid tumours. Sixty non-neutropenic febrile episodes (41 in CMV-seropositive and 19 in CMV-seronegative patients) were evaluated. CMV reactivation, documented by CMV antigenaemia, was detected in 16 out of 41 (39%) seropositive patients compared with 0 out of 19 seronegative patients. In 12 of these 16 patients, CMV infection was considered the sole cause of fever. Thirteen patients had maximum antigenaemia levels > 5 cells/slide. Specific antiviral treatment led to the resolution of the fever in all, but two, patients, who developed fatal CMV pneumonia. Patients with multiple myeloma and lymphoma, possibly owing to a combination of disease-related characteristics and prior immuno-suppressire treatment, had high rates of CMV reactivation and may require more frequent diagnostic evaluation and prompt therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalBritish journal of haematology
Volume112
Issue number1
DOIs
StatePublished - Feb 24 2001
Externally publishedYes

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Keywords

  • Autologous stem cell transplantation
  • Cytomegalovirus
  • Lymphoma
  • Multiple myeloma
  • Non-neutropenic fever

ASJC Scopus subject areas

  • Hematology

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