Cytomegalovirus in tears from patients with normal eyes and with acute cytomegalovirus chorioretinitis

F. Cox, D. Meyer, W. T. Hughes

Research output: Contribution to journalArticlepeer-review


Cytomegalovirus (CMV) was recovered from the tears in eight of 41 (19.5%) children excreting CMV in their urine or saliva. Tear excretors were all immunosuppressed children with acute lymphocytic leukemia. Three had active CMV chorioretinitis and five did not develop retinal disease in nine to 15 months of observation. To our knowledge this was the first report of the recovery of CMV from tears and of acquired CMV chorioretinitis in children. One patient with active chorioretinitis presented with a disciform elevation of the macula. Therapy with adenine arabinoside (ara-A) or idoxuridine was ineffective in two patients while a third patient treated with ara-A possibly had a more rapid recovery. However, the significance is uncertain due to the unusual disease presentation and lack of data regarding the nature of cytomegalic inclusion disease chorioretinitis. Areas of retinal calcification were present at autopsy in one patient.

Original languageEnglish (US)
Pages (from-to)817-824
Number of pages8
JournalAmerican journal of ophthalmology
Issue number5
StatePublished - Nov 1975
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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