Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women

Christina M. Parrinello, Elizabeth Sinclair, Alan L. Landay, Nell Lurain, A. Richey Sharrett, Stephen J Gange, Xiaonan Xue, Peter W. Hunt, Steven G. Deeks, Howard N. Hodis, Robert C. Kaplan

Research output: Contribution to journalArticle

Abstract

Background. Cytomegalovirus (CMV) infection has been implicated in immune activation and accelerated progression of immunodeficiency from human immunodeficiency virus (HIV) coinfection. We hypothesized that CMV is associated with vascular disease in HIV-infected adults.Methods.In the Women's Interagency HIV Study, we studied 601 HIV-infected and 90 HIV-uninfected participants. We assessed the association of CMV immunoglobulin G (IgG) level with carotid artery intima-media thickness, carotid artery distensibility, Young's elastic modulus, and blood pressures. Multivariable models adjusted for age, race/ethnicity, smoking, diabetes, and body mass index.Results.Mean CMV IgG levels were higher in HIV-infected women compared with HIV-uninfected women (P

Original languageEnglish (US)
Pages (from-to)1788-1796
Number of pages9
JournalJournal of Infectious Diseases
Volume205
Issue number12
DOIs
StatePublished - Jun 15 2012

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Carotid Artery Diseases
Cytomegalovirus
Immunoglobulin G
HIV
Antibodies
Elastic Modulus
Carotid Arteries
Carotid Intima-Media Thickness
Cytomegalovirus Infections
Coinfection
Vascular Diseases
Body Mass Index
Smoking
Blood Pressure

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women. / Parrinello, Christina M.; Sinclair, Elizabeth; Landay, Alan L.; Lurain, Nell; Sharrett, A. Richey; Gange, Stephen J; Xue, Xiaonan; Hunt, Peter W.; Deeks, Steven G.; Hodis, Howard N.; Kaplan, Robert C.

In: Journal of Infectious Diseases, Vol. 205, No. 12, 15.06.2012, p. 1788-1796.

Research output: Contribution to journalArticle

Parrinello, CM, Sinclair, E, Landay, AL, Lurain, N, Sharrett, AR, Gange, SJ, Xue, X, Hunt, PW, Deeks, SG, Hodis, HN & Kaplan, RC 2012, 'Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women', Journal of Infectious Diseases, vol. 205, no. 12, pp. 1788-1796. https://doi.org/10.1093/infdis/jis276
Parrinello, Christina M. ; Sinclair, Elizabeth ; Landay, Alan L. ; Lurain, Nell ; Sharrett, A. Richey ; Gange, Stephen J ; Xue, Xiaonan ; Hunt, Peter W. ; Deeks, Steven G. ; Hodis, Howard N. ; Kaplan, Robert C. / Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women. In: Journal of Infectious Diseases. 2012 ; Vol. 205, No. 12. pp. 1788-1796.
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AU - Gange, Stephen J

AU - Xue, Xiaonan

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